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Clip	Code No.	Product					Data
Data Sheet	Isotype	Clone	Conjugate	Size	Price	Availability
	Application			Reactivity		Storage temp.
	PD048	Anti-OsTIR1 pAb
	Rabbit IgG	Polyclonal	Unlabeled	100 µL	￥52,800	10 or more
	WB / IC*			Other		-20°C
	D058-11	Anti-Multi Ubiquitin mAb-Magnetic Beads
	Mouse IgG1 κ	FK2	Magnetic Beads	20 tests (Slurry: 1 mL)	￥52,800	10 or more
	IP			Hu		4°C
	D365-3	Anti-PIWIL2 (MILI) (Mouse) mAb
	Mouse IgG2aκ	3G5-E6	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP / IH			Mo / Rat**		-20°C
	PM098	Anti-Inosine pAb
	Rabbit Ig (aff.)		Unlabeled	100 µL	￥66,000	10 or more
	IP / IC / IH** / ELISA / DB					-20°C
	MEX003-12	Anti-CD81 (TAPA1) mAb-ALP
	Mouse IgG2aκ	A103-10	AP	50 µL	￥63,800	10 or more
	ELISA			Hu		4°C
	MEX002-12	Anti-CD63 (LAMP-3) mAb-ALP
	Mouse IgG2bκ	C047-1	AP	50 µL	￥63,800	10 or more
	ELISA			Hu		4°C
	MEX001-12	Anti-CD9 mAb-ALP
	Mouse IgG2aκ	A100-4	AP	50 µL	￥63,800	1-9
	ELISA			Hu		4°C
	RN017M	Anti-7-methylguanosine (m7G) mAb
	Mouse IgG2aκ	4141-13	Unlabeled	200 µL (1 mg/mL)	￥66,000	10 or more
	IP / IC / ELISA / DB / Other*					-20°C
	RN016M	Anti-7-methylguanosine (m7G)-Cap mAb
	Mouse IgG2aκ	150-15	Unlabeled	200 µL (1 mg/mL)	￥66,000	10 or more
	IP / IC / ELISA / DB					-20°C
	RN019M	Anti-2,2,7-trimethylguanosine (m3G/TMG) mAb
	Mouse IgG2aκ	235-1	Unlabeled	200 µL (1 mg/mL)	￥66,000	10 or more
	IP / IC					-20°C
	PM096	Anti-PER2 (Human) pAb
	Guinea pig Ig (aff.)	Polyclonal	Unlabeled	50 µL	￥52,800	10 or more
	WB / IP			Hu		-20°C
	MEX003-6	Anti-CD81 (TAPA1) mAb-Biotin
	Mouse IgG2aκ	A103-10	Biotin	50 µL (1 mg/mL)	￥35,200	10 or more
	WB / FCM / ELISA / Other			Hu		4°C
	MEX002-6	Anti-CD63 (LAMP-3) mAb-Biotin
	Mouse IgG2bκ	C047-1	Biotin	50 µL (1 mg/mL)	￥35,200	1-9
	WB / FCM / ELISA / Other			Hu		4°C
	MEX001-6	Anti-CD9 mAb-Biotin
	Mouse IgG2aκ	A100-4	Biotin	50 µL (1 mg/mL)	￥35,200	10 or more
	WB / FCM / ELISA / Other			Hu		4°C
	RN128PW	Anti-TRMT6 (Human) pAb
	Rabbit Ig (aff.)	Polyclonal	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP			Hu / Ham(w)		-20°C
	RN127PW	Anti-NSUN2 (Human) pAb
	Rabbit Ig (aff.)	Polyclonal	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP			Hu		-20°C
	RN126PW	Anti-AHCY (SAHH) pAb
	Rabbit Ig (aff.)	Polyclonal	Unlabeled	100 µL	￥52,800	10 or more
	WB / IP			Hu / Mo / Rat / Ham / Thale Cress		-20°C
	RN125PW	Anti-HENMT1 pAb
	Rabbit Ig (aff.)	Polyclonal	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB			Hu / Mo / Rat		-20°C
	RN124PW	Anti-RNMT (Human) pAb
	Rabbit Ig (aff.)	Polyclonal	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP			Hu		-20°C
	RN123PW	Anti-YTHDF2 pAb
	Rabbit Ig (aff.)	Polyclonal	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP / IC*			Hu / Mo / Rat(w) / Ham		-20°C
	RN122PW	Anti-ALKBH5 pAb
	Rabbit Ig (aff.)	Polyclonal	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB / IP			Hu / Mo		-20°C
	M230-3	Anti-Parkin mAb
	Mouse IgG2aκ	Par6	Unlabeled	100 µL (1 mg/mL)	￥41,800	10 or more
	WB			Hu / Mo / Rat		-20°C
	PM092	Anti-NR1D1 (Rev-erbα) pAb
	Rabbit Ig (aff.)	Polyclonal	Unlabeled	100 µL	￥52,800	10 or more
	WB / IP			Hu / Mo / Rat		-20°C
	PM091	Anti-Per1 (Mouse) pAb
	Guinea pig IgG	Polyclonal	Unlabeled	100 µL	￥52,800	1-9
	WB / IP			Mo		-20°C
	PM093	Anti-NR1D2 (Rev-erbβ) pAb
	Guinea pig Ig (aff.)	Polyclonal	Unlabeled	100 µL	￥52,800	1-9
	WB / IP			Hu / Mo		-20°C
	PM090	Anti-Atg8 (Filamentous fungi) pAb
	Rabbit Ig (aff.)	Polyclonal	Unlabeled	100 µL	￥52,800	1-9
	WB					-20°C
	PM087	Anti-Chrono (Mouse) pAb
	Rabbit Ig (aff.)	Polyclonal	Unlabeled	100 µL	￥52,800	10 or more
	WB			Mo		-20°C
	M224-3	Anti-KEAP1 mAb
	Mouse IgG2aκ	KP1	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB			Hu / Mo / Rat / Ham		-20°C
	RN014MW	Anti-SFPQ (PSF) mAb
	Mouse IgG2aκ	C23	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP / IC / IH			Hu / Mo / Rat / Ham		-20°C
	RN013MW	Anti-Nono (P54NRB) mAb
	Mouse IgG2aκ	C5	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB / IP / IC / IH			Mo / Rat / Ham		-20°C
	MEX003-3	Anti-CD81 (TAPA1) mAb
	Mouse IgG2aκ	A103-10	Unlabeled	100 µL (1 mg/mL)	￥66,000	10 or more
	WB / IP / FCM / ELISA			Hu / Ham / Mky		-20°C
	MEX002-3	Anti-CD63 (LAMP-3) mAb
	Mouse IgG2bκ	C047-1	Unlabeled	100 µL (1 mg/mL)	￥66,000	10 or more
	WB / IP / FCM / ELISA			Hu / Mky		-20°C
	MEX001-3	Anti-CD9 mAb
	Mouse IgG2aκ	A100-4	Unlabeled	100 µL (1 mg/mL)	￥66,000	10 or more
	WB / IP / FCM / ELISA / Other*			Hu / Mky		-20°C
	CY-M1011	Anti-Phospho-MBS (MYPT1) (Thr696) mAb
	Mouse IgG1	AF20	Unlabeled	100 µg	￥55,000	0 (Contact us)
	WB / ELISA			Hu / Mo / Rat / Chi		-20°C
	CY-M1013	Anti-Phospho-Rb (Ser612) mAb
	Mouse IgG2a	3C11	Unlabeled	100 µg	￥55,000	1-9
	WB / IP / ELISA			Hu		-20°C
	CY-M1015	Anti-Phospho-Rb (Ser807) mAb
	Mouse IgG1	5H12	Unlabeled	100 µg	￥55,000	0 (Contact us)
	WB / IP / ELISA			Hu		-20°C
	CY-M1020	Anti-Phospho-Lats2 (Ser83) mAb
	Mouse IgG2b	ST-3B11	Unlabeled	100 µg	￥55,000	0 (Contact us)
	WB / ELISA			Hu		-20°C
	CY-M1023	Anti-Phospho-Syntide-2 mAb
	Mouse IgG2b	MS-6E6	Unlabeled	100 µg	￥55,000	1-9
	ELISA					-20°C
	CY-M1032	Anti-PCSK9 prodomain (Human) mAb
	Mouse IgG1	KS-2C8	Unlabeled	100 µg	￥55,000	1-9
	WB / IP			Hu		-20°C
	CY-M1033	Anti-PCSK9 (Human) mAb
	Mouse IgG1	KS-4H12	Unlabeled	100 µg	￥55,000	0 (Contact us)
	WB / IP			Hu		-20°C
	CY-M1038	Anti-RAGE (Human) mAb
	Mouse IgG1	YK-2B4	Unlabeled	100 µg/100µL	￥55,000	0 (Contact us)
	WB / FCM			Hu		-20°C
	CY-P1017	Anti-Adiponectin (Acrp30) pAb
	Rabbit IgG	Polyclonal	Unlabeled	50 µg	￥44,000	0 (Contact us)
	WB / IP			Hu / Mo / Rat		-20°C
	CY-P1025	Anti-Phospho-MBS (MYPT1) (Thr853) pAb
	Rabbit IgG	Polyclonal	Unlabeled	50 µg	￥55,000	1-9
	WB / ELISA			Hu / Mo / Rat / Chi		-20°C
	CY-P1037	Anti-PCSK9 (Human) pAb
	Rabbit IgG	Polyclonal	Unlabeled	100 µg	￥44,000	10 or more
	WB / IP			Hu		-20°C
	D058-3	Anti-Multi Ubiquitin mAb
	Mouse IgG1 κ	FK2	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IC* / IH* / ELISA*			Hu / Mo* / Mky* / Fruit fly* / Yeast*		-20°C
	D058-8	Anti-Multi Ubiquitin mAb-Agarose
	Mouse IgG1 κ	FK2	Agarose	Gel:200 µL (Slurry:400 µL)	￥52,800	10 or more
	IP			Hu		4°C
	D071-3	Anti-Multi Ubiquitin mAb
	Mouse IgM	FK1	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB			Hu / Mo*		-20°C
	D076-3	Anti-Phosphorylated Vimentin (Ser55) mAb
	Mouse IgG2b	4A4	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IC / IH* / ELISA*			Hu / Mo / Rat		-20°C
	D093-3	Anti-Phosphorylated Vimentin (Ser71) mAb
	Rat IgG2a	TM71	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IC			Hu / Mo / Rat		-20°C
	D095-3	Anti-Phosphorylated Vimentin (Ser82) mAb
	Mouse IgG2b	MO82	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB / IC / IH*			Hu / Mo / Rat		-20°C
	D128-3	Anti-Phospho-STAT3 (Tyr708) mAb
	Mouse IgG1	PS3/1	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB			Hu / Mo		-20°C
	D130-3	Anti-Runx2 (Cbfa1) mAb
	Mouse IgG2bκ	8G5	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP* / IC* / IH* / ELISA* / ChIP* / Co-IP*			Hu / Mo / Rat*		-20°C
	D138-3	Anti-Sap155 mAb
	Mouse IgG2b	1A5	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB			Hu / Mo / Ham		-20°C
	D147-3	Anti-Abi-1 (Abl interactor 1) mAb
	Mouse IgG1	1B9	Unlabeled	100 µL (1 mg/mL)	￥44,000	10 or more
	WB / IP / IC* / IH			Hu / Mo / Rat* / Ham / Dog*		-20°C
	D162-3	Anti-Flavocytochrome b558 (Human) mAb
	Mouse IgG1	7D5	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	FCM			Hu		-20°C
	D162-4	Anti-Flavocytochrome b558 (Human) mAb-FITC
	Mouse IgG1	7D5	FITC	100 µL (500 µg/mL)	￥33,000	10 or more
	FCM			Hu		4°C
	D162-5	Anti-Flavocytochrome b558 (Human) mAb-PE
	Mouse IgG1	7D5	PE	1 mL (50 tests)	￥33,000	10 or more
	FCM			Hu		4°C
	D164-3	Anti-NEU3 (Human) mAb
	Mouse IgG1 κ	11B	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP* / IC* / IH*			Hu		-20°C
	D221-3	Anti-Sap155 mAb
	Mouse IgG2b	16	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP / IC			Hu / Mo		-20°C
	D317-3	Anti-Stabilin-2 (Mouse) mAb
	Rat IgG2a	#34-2	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB* / FCM / IC / IH			Mo		-20°C
	D333-3	Anti-CLOCK (Mouse) mAb
	Mouse IgG1 κ	CLSP3	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP** / ChIP*			Hu / Mo		-20°C
	D334-3	Anti-CLOCK (Mouse) mAb
	Mouse IgG1 κ	CLNT1	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP*			Mo		-20°C
	D335-3	Anti-BMAL1 mAb
	Mouse IgG1 κ	B1BH2	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / ChIP*			Hu / Mo		-20°C
	D343-3	Anti-Phospho-p62 (SQSTM1) (Ser403) mAb
	Rat IgG2aκ	4F6	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IH			Hu / Mo		-20°C
	D343-3MS	Anti-Phospho-p62 (SQSTM1) (Ser403) mAb for My select sampler set
	Rat IgG2aκ	4F6	Unlabeled	20 µL (1 mg/mL)	￥16,500	0 (Contact us)
	WB / IH			Hu / Mo		-20°C
	D344-3	Anti-Phospho-p62 (SQSTM1) (Ser403) mAb
	Rat IgG2aκ	4C8	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IH			Hu / Mo		-20°C
	D344-3MS	Anti-Phospho-p62 (SQSTM1) (Ser403) mAb for My select sampler set
	Rat IgG2aκ	4C8	Unlabeled	20 µL (1 mg/mL)	￥16,500	0 (Contact us)
	WB / IH			Hu / Mo		-20°C
	D345-3	Anti-1-methyladenosine (m1A) mAb
	Mouse IgG2bκ	AMA-2	Unlabeled	100 µL (1 mg/mL)	￥66,000	10 or more
	IP / IC / IH / ELISA** / DB* / Other*					-20°C
	D346-3	Anti-5-methylcytidine (m5C) mAb
	Mouse IgG2aλ	FMC-9	Unlabeled	100 µL (1 mg/mL)	￥66,000	1-9
	IP / IC / IH / ELISA / DB / Other*					-20°C
	D347-3	Anti-Pseudouridine mAb
	Mouse IgG1 κ	APU-6	Unlabeled	100 µL (1 mg/mL)	￥66,000	10 or more
	IC / IH / ELISA* / Other*					-20°C
	D349-3	Anti-CLOCK mAb
	Mouse IgG1 κ	CLSP4	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP / IH / ChIP*			Hu / Mo		-20°C
	M001-3	Anti-HS1 mAb
	Mouse IgG1	3A3	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB / IP			Hu / Mo / Rat		-20°C
	M019-3	Anti-Nucleolin mAb
	Mouse IgG1	4E2	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP* / FCM / IC / IH / Other*			Hu / Bov* / Mky* / Dog*		-20°C
	M033-3	Anti-FADD mAb
	Mouse IgG1	1F7	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP*			Hu / Mo		-20°C
	M041-3	Anti-PML (Human) mAb
	Mouse IgG1	1B9	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP* / FCM / IC			Hu		-20°C
	M113-3	Anti-SUMO-1 mAb
	Mouse IgG1	5B12	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB / IC			Hu / Mo / Rat		-20°C
	M114-3	Anti-SUMO-2/3 mAb
	Mouse IgG2b	1E7	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IC / ChIP* / Other*			Hu / Mo / Rat		-20°C
	M133-3	Anti-Atg3 mAb
	Mouse IgG2bκ	3E8	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB / IP / IC			Hu / Mo / Rat / Ham		-20°C
	M134-3	Anti-Atg4B mAb
	Mouse IgG1	9H5	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB			Hu / Mo / Rat / Ham		-20°C
	M135-3	Anti-GABARAP mAb
	Mouse IgG1	1F4	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IC* / IH*			Hu / Mo / Rat / Ham / Chi*		-20°C
	M150-3	Anti-Atg16L mAb
	Mouse IgG1 κ	1F12	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / FCM* / IH*			Hu / Mo / Rat		-20°C
	M151-3	Anti-Atg10 (Human) mAb
	Mouse IgG1 κ	5A7	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB / IH*			Hu		-20°C
	M152-3	Anti-LC3 mAb
	Mouse IgG1 κ	4E12	Unlabeled	100 µL (2 mg/mL)	￥52,800	10 or more
	WB* / IP / FCM / IC / IH* / Other* / Other*			Hu / Mo / Rat / Ham		-20°C
	M152-3MS	Anti-LC3 mAb for My select sampler set
	Mouse IgG1 κ	4E12	Unlabeled	20 µL (2 mg/mL)	￥13,200	1-9
	WB* / IP / FCM / IC / IH* / Other*			Hu / Mo / Rat / Ham		-20°C
	M153-3	Anti-Atg5 mAb
	Mouse IgG1 κ	4D3	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB			Hu / Mo / Ham		-20°C
	M154-3	Anti-Atg12 (Human) mAb
	Mouse IgG1 κ	6E5	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP / IC			Hu		-20°C
	M160-3	Anti-UVRAG mAb
	Mouse IgG1 κ	1H4	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB / IP* / IC*			Hu / Mo / Rat / Ham		-20°C
	M162-3	Anti-p62 (SQSTM1) (Human) mAb
	Mouse IgG1 κ	5F2	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP / FCM / IC / IH			Hu		-20°C
	M162-3MS	Anti-p62 (SQSTM1) (Human) mAb for My select sampler set
	Mouse IgG1 κ	5F2	Unlabeled	20 µL (1 mg/mL)	￥13,200	0 (Contact us)
	WB / IP / FCM / IC / IH			Hu		-20°C
	M162-A48	Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor™ 488
	Mouse IgG1 κ	5F2	Alexa Fluor® 488	100 µL (1 mg/mL)	￥63,800	10 or more
	FCM / IC			Hu		4°C
	M162-A59	Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor™ 594
	Mouse IgG1 κ	5F2	Alexa Fluor® 594	100 µL (1 mg/mL)	￥63,800	1-9
	IC			Hu		4°C
	M162-A64	Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor™ 647
	Mouse IgG1 κ	5F2	Alexa Fluor® 647	100 µL (1 mg/mL)	￥63,800	10 or more
	FCM / IC			Hu		4°C
	M170-3	Anti-Rubicon (Human) mAb
	Mouse IgG2aκ	1H6	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB / IH			Hu		-20°C
	M184-3	Anti-Atg14 (Human) mAb
	Mouse IgG2aκ	4H8	Unlabeled	100 µL (1 mg/mL)	￥52,800	1-9
	WB / IP			Hu		-20°C
	M186-3	Anti-LC3 mAb
	Mouse IgG2aκ	8E10	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP*			Hu / Mo / Rat / Ham		-20°C
	M186-3MS	Anti-LC3 mAb for My select sampler set
	Mouse IgG2aκ	8E10	Unlabeled	20 µL (1 mg/mL)	￥13,200	10 or more
	WB / IP*			Hu / Mo / Rat / Ham		-20°C
	M186-7	Anti-LC3 mAb-HRP-DirecT
	Mouse IgG2aκ	8E10	HRP	50 µL	￥52,800	10 or more
	WB			Hu / Mo / Rat / Ham		4°C
	M191-3	Anti-FcεR1γ (FcRγ) (Mouse) mAb
	Mouse IgG1 κ	1D6	Unlabeled	100 µL (1 mg/mL)	￥52,800	10 or more
	WB / IP / FCM / IC			Mo		-20°C
	M191-A48	Anti-FcεR1γ (FcRγ) (Mouse) mAb-Alexa Fluor™ 488
	Mouse IgG1 κ	1D6	Alexa Fluor® 488	100 µL (1 mg/mL)	￥63,800	10 or more
	FCM / IC			Mo		4°C
	M191-A59	Anti-FcεR1γ (FcRγ) (Mouse) mAb-Alexa Fluor™ 594
	Mouse IgG1 κ	1D6	Alexa Fluor® 594	100 µL (1 mg/mL)	￥63,800	10 or more
	IC			Mo		4°C

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• The availability is based on the information in Japan at 00:05, Jul 1, 2024 in JST.
• The special price is shown in red color.
• Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
• Abbreviations for applications：
  WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
  FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
  ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
• For applications and reactivity:
  *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
  **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  
• For storage temparature: RT: room temparature
• Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.