Price
¥52,800
Availability (in Japan)
10 or more
(In Japan at 00:05,
Feb 9, 2025 in JST)
Size
100 µL (1 mg/mL)
Data | |||||
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Clonality | Monoclonal | Clone | 7D5 | ||
Isotype (Immunized Animal) | Mouse IgG1 | ||||
Applications | |||||
Immunogen (Antigen) | Human cytochrome b rich fraction | ||||
Reactivity [Gene ID] | |||||
Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | CYBA, p22-PHOX, CYBB, CGD, NOX2, IMD34, AMCBX2, GP91-1, GP91PHOX, p91-PHOX, GP91-PHOX | ||||
Background | The NADPH oxidase is a multicomponent enzyme that transfers electrons from NADPH to O2 to generate superoxide (O2-), a key part of the phagocytic or neutrophilic respiratory burst response. Flavocytochrome b558 is the catalytic component of the phagocyte NADPH oxidase. It is a transmembrane heterodimer composed of a large glycoprotein, gp91phox (PHagocyte OXidase) and a smaller protein, p22phox. Upon cell stimulation, flavocytochrome b558 assembles with p67phox, p47phox, and the GTP-binding protein Rac and becomes activated to generate O2-. Mutations in gp91phox, p22phox, or other components of the NADPH oxidase can result in chronic granulomatous disease, which is associated with significant morbidity and mortality due to a predisposition to recurrent bacterial and fungal infections. | ||||
Related products | D162-4 Anti-Flavocytochrome b558 (Human) mAb-FITC D162-5 Anti-Flavocytochrome b558 (Human) mAb-PE |
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Citations |
Flow Cytometry
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Product category |
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