Price
¥52,800
Availability (in Japan)
1-9
(In Japan at 17:00,
Feb 17, 2025 in JST)
Size
50 µL
Data | |||||
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Clonality | Monoclonal | Clone | 8E10 | ||
Isotype (Immunized Animal) | Mouse IgG2aκ | ||||
Applications | |||||
Immunogen (Antigen) | Human LC3 (MAP1LC3B), 1-120 aa (recombinant) | ||||
Reactivity [Gene ID] | |||||
Storage buffer | PBS/Preservative/Stabilizer | ||||
Storage temp. | 冷蔵 | Conjugate | HRP | Manufacturer | MBL |
Alternative names | microtubule-associated protein 1 light chain 3 beta, LC3B, ATG8F, MAP1LC3B-a, MAP1A/1BLC3, MAP1LC3B | ||||
Background | Macroautophagy mediates the bulk degradation of cytoplasmic components. These components are delivered to lysosomes via autophagosomes. The microtubule-associated protein 1 light chain 3 (LC3), a homologue of yeast Atg8 (Aut7/Apg8), localizes to autophagosomal membranes after post-translational modifications. The C-terminal fragment of LC3 is cleaved immediately following synthesis to yield a cytosolic form called LC3-I (18 kDa). A subpopulation of LC3-I is further converted to an autophagosome-associating form, LC3-II (16 kDa). This antibody can detect both forms of LC3. | ||||
Related products | 8486 Autophagy Watch M186-3 Anti-LC3 mAb PM036 Anti-LC3 pAb M152-3 Anti-LC3 mAb PD014 Anti-LC3 pAb 8485 Autophagy Ab Sampler Set PM036-PN Positive control for anti-LC3 antibody |
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Notes | Clone 8E10 reacts with LC3B and does not cross-react with LC3A, LC3C, GATE-16, and GABARAP. | ||||
Citations |
Western Blotting
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