|Isotype (Immunized Animal)||Rabbit Ig (aff.)|
|Reactivity [Gene ID]||
|Storage buffer||1 mg/mL in PBS/50% glycerol, pH 7.2|
|Alternative names||RNA (guanine-7-) methyltransferase, MET, Met, CMT1, cm1p, hMet, CMT1c, hCMT1, RG7MT1|
|Background||The 5’-terminal 7-methylguanosine cap (m7GpppN) is the unique structure added to the 5’-end of the nascent RNA through the pre-mRNA processing. The 7-methylguanosine cap protects the mRNA from degradation and acts as binding site for ribosome during translation initiation.
RNA (guanine-7-) methyltransferase (RNMT) is the enzyme that catalyzes the methylation of the guanosine cap at the N-7 position to produce the 7-methylguanosine cap. RNMT consists of a methyltransferase domain and an N-terminal non-catalytic domain that required for RNMT recruitment to transcription initiation sites.
|Related products||RN1001 RIP-Assay Kit
RN019M Anti-2,2,7-trimethylguanosine (m3G/TMG) mAb
RN016M Anti-7-methylguanosine (m7G)-Cap mAb
RN017M Anti-7-methylguanosine (m7G) mAb