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HOME > Product search results > Code No. M160-3 Anti-UVRAG mAb

Code No. M160-3

Anti-UVRAG mAb

Price

¥48,000

Availability (in Japan)

10 or more

(In Japan at 17:00,
Aug 6, 2020 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

Clonality Monoclonal Clone 1H4
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
WB
1 µg/mL  
IC*
reported.  (PMID: 22310240
IP*
reported.  (PMID: 25086043 / 26387534 / 28872463
Immunogen (Antigen) Recombinant Human UVRAG (389-699 a.a.)
Reactivity [Gene ID]

Human[7405], Mouse[78610], Rat[308846], Hamster[100751375]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names UV radiation resistance associated; p63, DHTX, VPS38
Background Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. UVRAG (UV irradiation resistance-associated gene) has been identified as an essential component of the Beclin 1-PI3KC3 complex that suppresses tumorigenicity of human colon and promotes Beclin 1 dependent autophagy.
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Citations

Western Blotting

  1. Kim J et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303 (2013)(PMID:23332761)
  2. Fulcher LJ et al. An affinity-directed protein missile system for targeted proteolysis. Open Biol. 6, 160255 (2016)(PMID:27784791)
  3. Cheng Z et al. Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. J Biol Chem. 292, 2065-2079 (2017)(PMID:27994061)
  4. Bartolomeo R et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 127, 3717-3729 (2017)(PMID:28872463)

Immunoprecipitation

  1. Kim J et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303 (2013)(PMID:23332761)
  2. Zhong Y et al. Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J Biol Chem. 289, 26021-37 (2014)(PMID:25086043)
  3. Nemazanyy I et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 6, 8283 (2015)(PMID:26387534)
  4. Bartolomeo R et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 127, 3717-3729 (2017)(PMID:28872463)

Immunocytochemistry

  1. Huang W et al. Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res. 22, 473-49 (2012)(PMID:22310240)
Product category
Research area
Autophagy
Apoptosis
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 17:00, Aug 6, 2020 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.