Price
¥52,800
Availability (in Japan)
10 or more
(In Japan at 00:05,
Feb 10, 2025 in JST)
Size
100 µL
Data | |||||
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Clonality | Polyclonal | Clone | Polyclonal | ||
Isotype (Immunized Animal) | Rabbit Ig (aff.) | ||||
Applications |
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Reactivity [Gene ID] | |||||
Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | IL3BP1, NFIL3A, NF-IL3A | ||||
Background | NFIL3, or E4BP4, is a transcription factor that controls sleep and circadian rhythms throughout the cranial nerve, endocrine, and metabolic systems.The circadian clock is a 24-hour endogenous oscillator, which cycles via transcriptional/translational feedback loops of clock genes and their products in individual cells. CLOCK and BMAL1 are positive factors in the loop, and their complex binds to E-box elements of PERs and CRYs. PER and CRY bind the CLOCK-BMAL1 complex, suppressing E-box-dependent transactivation and forming a molecular clock via this negative feedback mechanism.D-box and REV-ERB/ROR-binding elements also form a regulatory network of clock-controlled genes (CCGs). D-box-dependent transactivation is activated by DBP and repressed by NFIL3/E4BP4.NFIL3/E4BP4 expression also plays an important role in the immune system. NFIL3 polymorphisms are associated with inflammatory bowel disease (IBD). | ||||
Related products | PM096 Anti-PER2 (Human) pAb D335-3 Anti-BMAL1 mAb D334-3 Anti-CLOCK (Mouse) mAb D333-3 Anti-CLOCK (Mouse) mAb PM079 Anti-DBP (Mouse) pAb PM075 Anti-GNAT2 (Zebrafish) pAb PM081 Anti-Cry1 (Mouse) pAb PM082 Anti-Cry2 (Mouse) pAb PM083 Anti-Per2 (Mouse) pAb PM087 Anti-Chrono (Mouse) pAb PM091 Anti-Per1 (Mouse) pAb PM092 Anti-NR1D1 (Rev-erbα) pAb PM093 Anti-NR1D2 (Rev-erbβ) pAb D349-3 Anti-CLOCK mAb M219-3 Anti-RORγt mAb CY-1173 CycLex® CaM-kinase II Assay Kit |
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Citations |
Western Blotting
ChIP
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