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HOME > Product search results > Code No. RN016M Anti-7-methylguanosine (m7G)-Cap mAb

Code No. RN016M

Anti-7-methylguanosine (m7G)-Cap mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Sep 23, 2017 in JST)

Size

200 µg/200 µL

This antibody (Clone 150-15) reacts with 5&prime;-terminal 7-methylguanosine (m<sup>7</sup>G) cap structure of RNA and partially cross-reacts with m<sup>7</sup>G within RNA.
Data
  • Immunoprecipitation

  • Immunoprecipitation

  • Dot Blotting

Clonality Monoclonal Clone 150-15
Isotype (Immunized Animal) Mouse IgG2aκ
Applications
IP
10 &micro;g/sample  
IC
Can be used.  
ELISA
Can be used.  
DB
1 &micro;g/mL  
Immunogen (Antigen) Carrier protein-conjugated 7-methylguanosine (m<sup>7</sup>G)-Cap analogue
Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names 5&rsquo;-cap, 7mGppp, m7G(5&prime;)ppp(5&prime;)X
Background The 7-methylguanosine (m<sup>7</sup>G) cap, also known as m7G(5&prime;)ppp(5&prime;)X, is a specific structure located on the 5&prime;-terminus of the eukaryotic mRNA and in certain viral RNAs. This cap structure is also found at the 5&prime;-terminus of mRNA-like lncRNA and pri-miRNA. The m<sup>7</sup>G cap is primarily involved in the translation of mRNAs. It is also responsible for the stability of the mRNA, and promotes transcription, splicing, polyadenylation, and nuclear export of the mRNA.
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References
  1. Rottman F et al. Sequences containing methylated nucleotides at the 5' termini of messenger RNAs: possible implications for processing. Cell 3, 197-9 (1974)(PMID: 4373171
  2. Cowling VH. Regulation of mRNA cap methylation. Biochem J. 425, 295-302 (2009)(PMID: 20025612
  3. Ramanathan A et al. mRNA capping: biological functions and applications. Nucleic Acids Res. (2016) In press.(PMID: 27317694
Product category
Research area
RNA-RNP Network
Epigenetics
Brands
RiboCluster Profiler™
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Sep 23, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.