［Normal Tissue-derived］

Ebisudani T et al. Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening. Cell Rep. 2021, vol.35(10), 109218. [PMID: 34038715 ]

［Normal Tissue-derived］

Yachida S et al. Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System. Cancer Discov. 2022, vol.12(3), p.692-711. [PMID: 34880079 ]

［Normal Tissue／Tumor-derived］

Nanki K et al. Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis, Cell. 2018, vol.174(4), p.856-869.e17. [PMID: 30096312 ]

［Tumor-derived］

Togasaki K et al. Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer. Gastroenterology. 2021, vol.160(3), p.823-830. [PMID: 33217450 ]

［Tumor-derived］

Wang Z et al. Conversion therapy of intrahepatic cholangiocarcinoma is associated with improved prognosis and verified by a case of patient-derived organoid. Cancers (Basel). 2021, vol.13(5), 1179 . [PMID: 33803322 ]

［Normal Tissue／Tumor-derived］

Seino T et al. Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression, Cell Stem Cell. 2018, vol.22(3), p.454-467.e6. [PMID: 29337182 ]

Tiriac H et al. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov. 2018, vol.8(9), p.1112-1129. [PMID: 29853643 ]

Somerville TDD et al. TP63-mediated enhancer reprogramming drives the squamous subtype of pancreatic ductal adenocarcinoma. Cell Rep. 2018, vol.25(7), p.1741-1755.e7. [PMID: 30428345 ]

［Tumor-derived］

Roe JS et al. Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell. 2017, vol.170(5), p.875-888.e20. [PMID: 28757253 ]

Tiriac H et al. Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment. Gastrointest Endosc. 2018, vol.87(6), p.1474-1480. [PMID: 29325707 ]

Miyabayashi K et al. Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes, Cancer Discov. 2020, vol.10(10), p.1566-1589. [PMID: 32703770 ]

Farshadi EA et al. Organoids Derived from Neoadjuvant FOLFIRINOX Patients Recapitulate Therapy Resistance in Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2021, vol.27(23), p.6602-6612. [PMID: 34580113 ]

Ikezawa K et al. Establishment of organoids using residual samples from saline flushes during endoscopic ultrasound-guided fine-needle aspiration in patients with pancreatic cancer. Endosc Int Open. 2022, vol.10(1), p.E82-E87. [PMID: 35036290 ]

Nelson JK et al. USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer. Nat Commun. 2022, vol.13(1), 2070. [PMID: 35440539 ]

［Tumor-derived］

Wang Z et al. Lactate promotes the growth of patient-derived organoids from hepatopancreatobiliary cancers via ENO1/HIF1α pathway and does not affect their drug sensitivities. Cell Death Discov. 2022, vol.8(1), 214. [PMID: 35443744 ]

［Normal Tissue-derived］

Mihara E et al. Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin, Elife. 2016, 5:e11621. [PMID: 26902720 ]

Sugimoto S et al. Reconstruction of the Human Colon Epithelium In Vivo, Cell Stem Cell. 2018, vol.22(2), p.171-176.e5. [PMID: 29290616 ]

Sugimoto S, Fujii M, Sato T., Organoid Derivation and Orthotopic Xenotransplantation for Studying Human Intestinal Stem Cell Dynamics, Methods Mol Biol. 2020, 2171, p.303-320. [PMID: 32705652 ]

Sasaki N et al. Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium, Gastroenterology. 2020, vol. 159(1), p.388-390.e5. [PMID: 32199883 ]

Zwiggelaar RT et al. LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium, Sci Adv. 2020, vol, 6(37): eabc0367. [PMID: 32917713 ]

Fujii M et al. Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition, Cell Stem Cell. 2018, vol.23(6), p.787-793.e6. [PMID: 30526881 ]

Nanki K et al. Somatic inflammatory gene mutations in human ulcerative colitis epithelium, Nature. 2020, vol.577(7789), p.254-259. [PMID: 31853059 ]

Schuster B et al. Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids. Nat Commun. 2020, vol.11(1),5271. [PMID: 33077832 ]

Sugimoto S et al. An organoid-based organ-repurposing approach to treat short bowel syndrome. Nature. 2021, vol.592(7852), p.99-104. [PMID: 33627870 ]

De Oliveira T et al. Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo. Cancers (Basel). 2021, vol.13(5), 1011. [PMID: 33671096 ]

Genshaft AS et al. Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes. Nat Commun. 2021, vol.17;12(1), 4995. [PMID: 34404785 ]

Yachida S et al. Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System, Cancer Discov. 2022, vol.12(3), p.692-711. [PMID: 34880079 ]

［Normal Tissue／Tumor-derived］

Toshimitsu K et al. Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer. Nat Chem Biol. 2022, vol.18(6), p.605-614. [PMID: 35273398 ]

［Tumor-derived］

Kawasaki K et al. Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma. Gastroenterology. 2020, vol.158(3), p.638-651.e8. [PMID: 31622618 ]

Cho YW et al. Patient-derived organoids as a preclinical platform for precision medicine in colorectal cancer. Mol Oncol. 2022, vol.16(12), p.2396-2412. [PMID: 34850547 ]

［Tumor-derived］

Cao C et al. Phenotypical screening on metastatic PRCC-TFE3 fusion translocation renal cell carcinoma organoids reveals potential therapeutic agents. Clin Transl Oncol. 2022, vol.24(7), p.1333-1346. [PMID: 35118587 ]

［iPSC-derived］

Mae SI et al. Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential, Cell Rep. 2020, vol.32(4), 107963. [PMID: 32726627 ]

Ryosaka M et al. Protocol for the generation and expansion of human iPS cell-derived ureteric bud organoids. STAR Protoc. 2022, vol.3(3), 101484. [PMID: 35769929 ]

［Tumor-derived］

Nanki Y et al. Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing, Sci Rep. 2020, vol.10(1), 12581. [PMID: 32724113 ]

［Tumor-derived］

Wakamatsu T et al. Establishment of Organoids From Human Epithelioid Sarcoma With the Air-Liquid Interface Organoid Cultures. Front Oncol. 2022, vol.12, Article 893592. [PMID: 35677170 ]

［Gastroenteropancreatic Neuroendocrine Neoplasms-derived］

Kawasaki K et al. An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping. Cell. 2020, vol.183(5), p.1420-1435. e21. [PMID: 33159857 ]

［Normal Tissue-derived］

Kim D et al. 3D Organoid Culture From Adult Salivary Gland Tissues as an ex vivo Modeling of Salivary Gland Morphogenesis. Front Cell Dev Biol. 2021, vol.9, Article 698292. [PMID: 34458260 ]

［Normal Tissue-derived］

Takeuchi A et al. Suppressed cellular senescence mediated by T-box3 in aged gastric epithelial cells may contribute to aging-related carcinogenesis. Cancer Research Communications. 2022, vol. 2(8), p.772–783. [https://doi.org/10.1158/2767-9764.CRC-22-0084 ]

［Normal Tissue-derived］

Li Y et al. Identification of trypsin-degrading commensals in the large intestine. Nature. 2022, vol.609(7927), p.582-589. [PMID: 36071157 ]

［Normal Tissue／Tumor-derived］

Oshima H et al. Stat3 is indispensable for damage-induced crypt regeneration but not for Wnt-driven intestinal tumorigenesis. FASEB J. 2019, vol.33(2), p.1873-1886. [PMID: 30156908 ]

［Tumor-derived］

Nishina T et al. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun. 2021, 12(1), 2281. [PMID: 33863879 ]