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HOME > Product search results > Code No. PM085 Anti-ZBTB24 pAb

Code No. PM085

Anti-ZBTB24 pAb

Price

¥48,000

Availability (in Japan)

1-9

(In Japan at 00:05,
Oct 15, 2019 in JST)

Size

100 µL

This antibody is suitable for detecting mouse ZBTB24 protein.
Data
  • Western Blotting

  • Immunoprecipitation

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Guinea pig Ig (aff.)
Applications
WB
1:1,000  
IP
2 µL/300 µL of cell extract from 1 x 106 cells/sample

 

 

※ Not recommended for human samples  

Immunogen (Antigen) Recombinant mouse ZBTB24 (C-terminus)
Reactivity [Gene ID]

Human[9841], Mouse[268294], Rat**

Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names BIF1, ICF2, PATZ2, KIAA0441, ZNF450
Background ZBTB24 is a member of the Zinc finger and BTB domain-containing protein family. ZBTB24 consists of a BTB domain, an AT-hook DNA binding motif, and 8 C2H2-type zinc fingers. Mutations in the ZBTB24 gene are responsible for type 2 ICF (Immunodeficiency, Centromeric instability and Facial anomalies) syndrome, which shows hypomethylation of centromeric and pericentromeric satellite repeats. Because ZBTB24 localizes to pericentromeric heterochromatin, this protein may play an important role in formation and/or maintenance of pericentromeric heterochromatin.
Related products PM086 Anti-ZBTB24 (Human) pAb
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PM077 Anti-5-hydroxymethylcytosine (5hmC) pAb
M202-3 Anti-Np95 (Uhrf1) mAb
D289-3 Anti-Np95 (Uhrf1) (Mouse) mAb
PM067 Normal Guinea Pig IgG
Citations

Western Blotting

  1. Wu H et al. Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals. Hum Mol Genet. (2016) In press.(PMID:27466202)
References
  1. Nitta H et al. J Hum Genet. Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients. J Hum Genet. 58, 455-60 (2013)(PMID: 23739126
  2. Weemaes CM et al. Heterogeneous clinical presentation in ICF syndrome: correlation with underlying gene defects. Eur J Hum Genet. 21, 1219-25 (2013)(PMID: 23486536
  3. Cerbone M et al. Immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome, due to ZBTB24 mutations, presenting with large cerebral cyst. Am J Med Genet A. 158A, 2043-6 (2012)(PMID: 22786748
  4. Chouery E et al. A novel deletion in ZBTB24 in a Lebanese family with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. Clin Genet. 82, 489-93 (2012)(PMID: 21906047
  5. de Greef JC et al. Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. Am J Hum Genet. 88, 796-804 (2011)(PMID: 21596365
Product category
Research area
Epigenetics
Brands
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  • The availability is based on the information in Japan at 00:05, Oct 15, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.