Price
¥66,000
Availability (in Japan)
10 or more
(In Japan at 17:00,
Nov 9, 2024 in JST)
Size
100 µL
Data | |||||
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Clonality | Polyclonal | Clone | Polyclonal | ||
Isotype (Immunized Animal) | Rabbit Ig (aff.) | ||||
Applications |
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Immunogen (Antigen) | BSA-conjugated 5-hydroxymethylcytidine | ||||
Storage buffer | PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | 5-hmC | ||||
Background | DNA methylation is one of many critical epigenetic modifications. In most cases, cytosine (C) in DNA sequence is converted to 5-methylcytosine (5mC) with addition of a methyl group by the enzymatic activity of DNA methyltransferase. DNA methylation plays a role in the regulation of gene expression. It has been reported that abnormal DNA methylation level is involved in many diseases.
5-hydroxymethylcytosine (5hmC), a newly identified epigenetic modification following 5mC, is generated from oxidation of 5mC by the enzymatic activity of TET family proteins. 5hmC may function as a regulator of gene expression as well as 5mC. |
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Related products | MI-11-3 Anti-Bromodeoxyuridine mAb MI-11-5 Anti-Bromodeoxyuridine mAb-PE D345-3 Anti-1-methyladenosine (m1A) mAb D346-3 Anti-5-methylcytidine (m5C) mAb PM035 Normal Rabbit IgG PM085 Anti-ZBTB24 pAb PM086 Anti-ZBTB24 (Human) pAb D347-3 Anti-Pseudouridine mAb M227-3 Anti-Digoxigenin (DIG) mAb M218-3 Anti-5-hydroxymethylcytosine (5hmC) mAb M228-3 Anti-FITC mAb RN019M Anti-2,2,7-trimethylguanosine (m3G/TMG) mAb RN016M Anti-7-methylguanosine (m7G)-Cap mAb RN017M Anti-7-methylguanosine (m7G) mAb PM098 Anti-Inosine pAb |
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