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HOME > Product search results > Code No. D344-3MS Anti-Phospho-p62 (SQSTM1) (Ser403) mAb for My select sampler set

Code No. D344-3MS

Anti-Phospho-p62 (SQSTM1) (Ser403) mAb for My select sampler set

Price

¥9,600

Availability (in Japan)

10 or more

(In Japan at 17:00,
Oct 23, 2019 in JST)

Size

20 µg/20 µL

Data
  • Western Blotting

  • Immunohistochemistry

Clonality Monoclonal Clone 4C8
Isotype (Immunized Animal) Rat IgG2aκ
Applications
WB
5 µg/mL  
IH
5 µg/mL  
Immunogen (Antigen) synthetic peptide CKKKESLSQMLpSMGFSDEGKKK (corresponding to amino acid residues 396-410 of human p62 (SQSTM1))
Reactivity [Gene ID]

Human[8878], Mouse[18412]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names sequestosome-1, A170, OSIL, PDB3, ZIP3
Background p62/SQSTM1 is a major adaptor protein for selective autophagy. S403 is in a highly conserved ubiquitin association (UBA) domain of p62 and is directly phosphorylated by CK2 or TBK1. The S403 phosphorylation of p62 results in the enhanced binding affinity between p62 and polyubiquitin chain and induces its autophagic degradation. S403 phosphorylated p62 is concentrated in autophagosomes that is accumulated by Bafilomycin A1 treatment and in ubiquitin positive protein aggregates in autophagy deficient cells.      Clone 4C8 recognizes S403-phosphoryalted p62, but is different from clone 4F6.
Related products D343-3 Anti-Phospho-p62 (SQSTM1) (Ser403) mAb
PM074 Anti-Phospho-p62 (SQSTM1) (Ser351) pAb
PM045 Anti-p62 (SQSTM1) pAb
M162-3 Anti-p62 (SQSTM1) (Human) mAb
PM066 Anti-p62 C-terminal pAb
M162-A48 Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor® 488
M162-A59 Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor® 594
M162-A64 Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor® 647
References
  1. Matsumoto G et al. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. Mol Cell. 44, 279-89 (2011)
Product category
Research area
Autophagy
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  • The availability is based on the information in Japan at 17:00, Oct 23, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.