Anti-IGF2BP1 (IMP1) mAb

Price

¥66,000

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 16, 2024 in JST）

Size

200 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Western Blotting Immunoprecipitation RNP Immunoprecipitation
Clonality	Monoclonal	Clone	6H6
Isotype (Immunized Animal)	Mouse IgG2aκ
Applications	WB 1 μg/mL IP 5 μg/500 μL of cell extract from 5 x 10⁶ cells RIP 15 μg/500 μL of cell extract from 1 x 10⁷ cells
Immunogen (Antigen)	Recombinant full length IGF2BP1
Reactivity [Gene ID]	Human[10642], Mouse[140486]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	insulin-like growth factor binding protein 1, CRD-BP, CRDBP, IMP-1, VICKZ1, ZBP1
Background	Localization of IGF2 mRNA-binding protein 1 (IMP1) is associated with motility, and the major functions of IMP1 are carried out by the phylogenetically conserved K homology (KH) domains. IMP1 can affect stability, localization, and translation of its target RNAs. Binding of IMP1 to the leader 3 mRNA in the 5’-untranslated region (UTR) of IGF2 inhibits translation from a leader 3 reporter mRNA. Aberrant IMP1 expression may interfere with c-myc regulation. In tumors, gains at 8q24 (c-myc locus) were observed to be more frequent than those at 17q21 (IMP1 locus). Furthermore, IMP1 expression was frequently detected in tumors, implying that the mechanism of activation is other than that of gene amplification.
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Citations	Western Blotting Cassar PA et al. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. EMBO Rep. 16, 1334-57 (2015)(PMID:26265008)
Product category	Research area RNA-RNP Network Cancer Neuroscience Brands RiboCluster Profiler™

The availability is based on the information in Japan at 00:05, Apr 16, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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