Price
¥52,800
Availability (in Japan)
1-9
(In Japan at 00:05,
Jun 30, 2024 in JST)
Size
100 µL (1 mg/mL)
Data | |||||
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Clonality | Monoclonal | Clone | 4G4 | ||
Isotype (Immunized Animal) | Mouse IgG2aκ | ||||
Applications | |||||
Immunogen (Antigen) | Recombinant protein corresponding to amino acid residues 109-266 of mouse IL-33 | ||||
Reactivity [Gene ID] | Human(-), Mouse[77125], Rat(-) |
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Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | interleukin 33, Il33 | ||||
Background | The Interleukin-1 (IL-1) family, such as IL-1a/b and IL-18, has important functions in host defense, immune regulation, and inflammation. IL-33, a member of the IL-1 family, that shows to induce T helper (Th) type 2 responses by signaling through the IL-1 receptor-related protein ST2 (IL-1R4), an orphan member of the IL-1 receptor family. Similarly to IL-1a/b and IL-18, IL-33 is synthesized as a 31 kDa precursor protein has been shown to be cleaved by caspase-1 in vitro. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 has been originally identified as NF-HEV, which is a nuclear factor preferentially expressed in high endothelial venules. IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor involved in transcriptional regulation. | ||||
Related products | M138-3 Anti-IL-33 (Human) mAb M187-3 Anti-IL-33 (Mouse) mAb (Functional Grade) M188-3 Anti-IL-33 (Mouse) mAb (Functional Grade) PM033 Anti-IL-33 (Human) pAb D358-3 Anti-IL-38 (IL1F10) (Human) mAb D359-3 Anti-IL-38 (IL1F10) (Human) mAb |
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Citations |
Western Blotting
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Product category |
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