Anti-IL-33 (Human) pAb

Price

¥52,800

Availability (in Japan)

10 or more

（In Japan at 17:00,
Apr 18, 2024 in JST）

Size

100 µL

Citations

Data Sheet

SDS

Data	Western Blotting
Clonality	Polyclonal	Clone	Polyclonal
Isotype (Immunized Animal)	Rabbit Ig (aff.)
Applications	WB 1:500 IC* reported. （PMID: 22460292） IH 1:500-1:1,000 (Heat treatment is necessary for paraffin embedded sections.) IF* reported. （PMID: 33098728）
Immunogen (Antigen)	Recombinant Human full length IL-33 (270 a.a.)
Reactivity [Gene ID]	Human[90865]
Storage buffer	PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Background	Interleukin-1 (IL-1) family, such as IL-1a/b and IL-18, have important functions in host defense, immune regulation, and inflammation. IL-33, a member of the IL-1 family, that shows to induce T helper (Th) type 2 responses by signaling through the IL-1 receptor-related protein ST2 (IL-1R4), an orphan member of the IL-1 receptor family. Similarly to IL-1α/β and IL-18, IL-33 is synthesized as a 31 kDa precursor protein has been shown to be cleaved by caspase-1 in vitro. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 has been originally identified as NF-HEV, which is a nuclear factor preferentially expressed in high endothelial venules. IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor involved in transcriptional regulation.
Related products	M161-3 Anti-IL-33 (Mouse) mAb D358-3 Anti-IL-38 (IL1F10) (Human) mAb D359-3 Anti-IL-38 (IL1F10) (Human) mAb
Citations	Western Blotting Nomura K et al. Regulation of interleukin-33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines. Laryngoscope 122, 1185-92 (2012)(PMID:22460292) Immunocytochemistry Nomura K et al. Regulation of interleukin-33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines. Laryngoscope 122, 1185-92 (2012)(PMID:22460292) Immunohistochemistry Matsuda A et al. The role of interleukin-33 in chronic allergic conjunctivitis. Invest Ophthalmol Vis Sci. 50, 4646-52 (2009)(PMID:19458329) Guo Z et al. IL-33 promotes airway remodeling and is a marker of asthma disease severity. J Asthma. 51, 863-9 (2014)(PMID:24796648) Abe K et al. Interleukin-33/ST2-Mediated Inflammation Plays a Critical Role in the Pathogenesis and Severity of Type I Autoimmune Hepatitis. Hepatol Commun. 3, 670-684 (2019)(PMID:31061955) Nagaoka S et al. The blockade of interleukin-33 released by hepatectomy would be a promising treatment option for cholangiocarcinoma. Cancer Sci. 112, 347-358 (2021) (PMID:33098728) Immunofluorescence Nagaoka S et al. The blockade of interleukin-33 released by hepatectomy would be a promising treatment option for cholangiocarcinoma. Cancer Sci. 112, 347-358 (2021) (PMID:33098728)
Product category	Research area Immunology Cytokine & Growth Factors

The availability is based on the information in Japan at 17:00, Apr 18, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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