Antibody detailed product information

Code No.	M161-3
Anti-IL-33 (Mouse) mAb
Price	¥52,800
Size	100 µL (1 mg/mL)
Availability (in Japan)	1-9 （In Japan at 17:00, Apr 26, 2024 in JST）
Clonality	Monoclonal
Clone	4G4
Isotype (Immunized Animal)	Mouse IgG2aκ
Applications	WB　1 µg/mL IP　2 µg/sample
Immunogen (Antigen)	Recombinant protein corresponding to amino acid residues 109-266 of mouse IL-33
Reactivity [Gene ID]	Human(-), Mouse[77125], Rat(-)
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	interleukin 33, Il33
Background	The Interleukin-1 (IL-1) family, such as IL-1a/b and IL-18, has important functions in host defense, immune regulation, and inflammation. IL-33, a member of the IL-1 family, that shows to induce T helper (Th) type 2 responses by signaling through the IL-1 receptor-related protein ST2 (IL-1R4), an orphan member of the IL-1 receptor family. Similarly to IL-1a/b and IL-18, IL-33 is synthesized as a 31 kDa precursor protein has been shown to be cleaved by caspase-1 in vitro. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 has been originally identified as NF-HEV, which is a nuclear factor preferentially expressed in high endothelial venules. IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor involved in transcriptional regulation.
Related products	M138-3 Anti-IL-33 (Human) mAb M187-3 Anti-IL-33 (Mouse) mAb (Functional Grade) M188-3 Anti-IL-33 (Mouse) mAb (Functional Grade) PM033 Anti-IL-33 (Human) pAb D358-3 Anti-IL-38 (IL1F10) (Human) mAb D359-3 Anti-IL-38 (IL1F10) (Human) mAb
Product category	Research area:Immunology Cytokine & Growth Factors
Data
Citations	Western Blotting Ohno T et al. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J Immunol. 183, 7890-7 (2009)(PMID:19933859)

The availability is based on the information in Japan at 17:00, Apr 26, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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