トップ > 製品検索結果一覧 > Code No. M059-3 Anti-Caspase-10 (Human) mAb

Code No. M059-3

Anti-Caspase-10 (Human) mAb

価格(税別)

¥48,000

在庫

10以上

(2022/08/10 17:00時点)

包装

100 µg/100 µL

This antibody detects specifically 57 and 58 kDa of human caspase-10, 43 kDa and 30 kDa of human active caspase-10 on Western blotting (Park SJ et al. J Biol Chem. 279; 51057-51067 (2004)). This antibody reacts with isoforms caspase-10/a, 10/b and 10/d (Kischkel FC et al. J Biol Chem. 276, 46639-46646 (2001))
データ
  • Western Blotting

クローナリティー Monoclonal クローン 4C1
アイソタイプ
(免疫動物)
Mouse IgG1 κ
使用法
WB
1-10 µg/mL  
免疫原(抗原) Recombinant full length Human FLICE2
交差性
[Gene ID]

Human[843], Mouse(-)

性状 1 mg/mL in PBS/50% glycerol, pH 7.2
保存温度 -20°C 標識 Unlabeled メーカー MBL
別称 CASP10, caspase 10, apoptosis-related cysteine peptidase, MCH4, ALPS2, FLICE2
背景 Apoptosis is a major form of cell death characterized by several morphological features that include chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signaling pathway that leads to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitment to cell death. Caspase-10 (also known as Mch4, FLICE2 and ICE-LAP4) is a ~58 kDa protein. This caspase acts upstream of the apoptosis induced cascade. Once this caspase is activated by certain apoptotic stimuli, this protein may be responsible for the activation of the other caspases such as caspase-3, -4, -7, -8, and -9. This antibody was made against human-originated immunogen, and detects human caspase-10 specifically.
関連製品 M032-3 Anti-Caspase-8 (Human) mAb
M058-3 Anti-Caspase-8 (Human) mAb
M054-3 Anti-Caspase-9 mAb
M097-3 Anti-Caspase-3 (Human) mAb
M087-3 Anti-Caspase-3 (Human) mAb
SY-001 Anti-Fas (CD95) (Human) mAb
M075-3 Mouse IgG1 (isotype control)
M029-3 Anti-Caspase-4 (Human) mAb
使用文献
使用文献募集中!本製品を使って論文を発表されましたら是非お知らせください。

Western Blotting

  1. Kischkel FC et al. Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J Biol Chem. 276, 46639-46 (2001)(PMID:11583996)
  2. Park SJ et al. J Biol Chem. Taxol induces caspase-10-dependent apoptosis. 279, 51057-67 (2004)(PMID:15452117)
  3. Koschny R et al. Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Clin Cancer Res. 13, 3403-12 (2007)(PMID:17545549)
  4. Hyer ML et al. Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer. Cancer Res. 68, 2927-33 (2008)(PMID:18413762)
  5. Verbrugge I et al. Ionizing radiation modulates the TRAIL death-inducing signaling complex, allowing bypass of the mitochondrial apoptosis pathway. Oncogene 27, 574-84 (2008)(PMID:17684487)
  6. Strauss G et al. CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling. J Exp Med. 206, 1379-93 (2009)(PMID:15452117)
  7. Lafont E et al. Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk. PLoS One 5, e13638 (2010)(PMID:21049020)
  8. Cazanave SC et al. Death receptor 5 signaling promotes hepatocyte lipoapoptosis. J Biol Chem. 286, 39336-48 (2011)(PMID:21941003)
  9. Estornes Y et al. dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death Differ. 19, 1482-94 (2012)(PMID:22421964)
  10. Schleich K et al. Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain. Cell Death Differ. 23, 681-94 (2016)(PMID:26494467)
  11. Visiedo F et al. Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus. Oxid Med Cell Longev. 2017, 5629341 (2017)(PMID:28400911)
  12. Pešková L et al. Human Embryonic Stem Cells Acquire Responsiveness to TRAIL upon Exposure to Cisplatin. Stem Cells Int. 2019, 4279481 (2019) (PMID:30805008)
  13. Kumari R et al. Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis. Nat Commun. 10, 4255 (2019)(PMID:31534141)
  14. Lee SR et al. Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis. Sci Rep. 9,13505 (2019) (PMID:31534206)
  15. Elmallah MIY et al. Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP. Cells. 9, 1760 (2020)(PMID:32708048)
製品
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分野
アポトーシス
この製品に関するお問い合わせをする

※在庫につきましては2022年08月10日 17時00分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について:
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
※使用法・交差性の表記について:
*: 論文で報告されております(MBLでは未確認)。詳しくはデータシートをご覧ください。
**: 導入元からの情報です(MBLでは評価中もしくは未確認)。
※保存温度の表記について: RT: 室温
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