トップ > 製品検索結果一覧 > Code No. D067-4 Anti-ST2 (Human) mAb-FITC

Code No. D067-4

Anti-ST2 (Human) mAb-FITC

価格(税別)

¥48,000

在庫

10以上

(2019/11/15 00:05時点)

包装

50 µg/100 µL

クローナリティー Monoclonal クローン 2A5
アイソタイプ
(免疫動物)
Mouse IgG1
使用法
FCM
10 µg/mL  
免疫原(抗原) Secreted form of ST7 purified from the culture supernatant of COS7 transfectant
交差性
[Gene ID]

Human[9173]

性状 PBS/1% BSA/0.09% NaN3
保存温度 4°C 標識 FITC メーカー MBL
別称 IL1RL1, interleukin 1 receptor-like 1, T1, DER4, ST2L, ST2V, FIT-1, IL33R
背景

The ST2 gene, also known as T1, Fit1, or DER4, was originally identified as a responsive gene that was highly induced by stimulation of various proliferation-inducing agents including serum, PDGF (platelet-derived growth factor), FGF (fibroblast growth factor), or lysophosphatidic acid in murine fibroblasts. Three distinct forms of gene products have been reported and named ST2, ST2V, and ST2L.

ST2 is a soluble secreted form of 37 kDa protein, which lacks intracellular domain, whereas ST2L is a transmembrane form of 62 kDa protein (the glycosylated forms of ST2 and ST2L are about 57 and 80 kDa, respectively). This ST2L protein is very similar to IL-1R (interleukin-1 receptor) type I and II in structure, thus it is considered as a member of the IL-1R family. ST2V, which is another novel variant form of human ST2, has been identified recently.ST2 proteins are expressed in the wide variety types of human cells, including hematopoietic cells in various stages of differentiation, a population of the peripheral blood mononuclear cells from healthy individuals, glioblastoma and astrocytoma cell lines, and colon cancer cells in addition to fibroblast cell lines. Thus ST2 proteins are considered to have some roles in regulating cell growth or proliferation. On the other hand, either definitive functions of ST2 proteins or their ligand molecule(s) which binds to ST2 proteins have remained unclear, though it has been reported that none of IL-1a, b, RA (receptor antagonist) binds to ST2 proteins in spite of their structural similarity to IL-1R. This indicates that ST2L protein is functionally independent from IL-1R. Furthermore, several studies have shown that ST2L is expressed on the cell surface of Th2 cells but not on the Th1 cells, indicating the possibility that ST2L protein participates not only in the regulation of cell growth or proliferation, but also in the immune system including differentiation of T cells or immunological response via helper T cells.From these observations, ST2 proteins are considered to be one of the important proteins participate in various physiological phenomenon, thus further analysis are required to understand its physiological functions.

関連製品 D067-3 Anti-ST2 (Human) mAb
D066-3 Anti-ST2 (Human) mAb
D065-3 Anti-ST2 (Human) mAb
D067-5 Anti-ST2 (Human) mAb-PE
使用文献
使用文献募集中!本製品を使って論文を発表されましたら是非お知らせください。
  1. Kim SJ et al. Preprogrammed, parallel on-chip immunoassay using system-level capillarity control. Anal Chem. 85, 6902-7 (2013)(PMID:23789820)

Flow Cytometry

  1. Pecaric-Petkovic T et al. Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. Blood 113, 1526-34 (2009)(PMID:18955562)
  2. Bianchetti L et al. IL-33 promotes the migration and proliferation of circulating fibrocytes from patients with allergen-exacerbated asthma. Biochem Biophys Res Commun. 426, 116-21 (2012)(PMID:22921786)
製品
カテゴリー
分野
がん
細胞膜表面抗原
この製品に関するお問い合わせをする

※在庫につきましては2019年11月15日 00時05分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について:
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
※使用法・交差性の表記について:
*: 論文で報告されております(MBLでは未確認)。詳しくはデータシートをご覧ください。
**: 導入元からの情報です(MBLでは評価中もしくは未確認)。
※保存温度の表記について: RT: 室温
※本サイトの掲載製品は、品質改良のため予告なく仕様などの変更、または販売中止となる場合がございます。あらかじめご了承ください。