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HOME > Product search results > Code No. PM078 Anti-Hemoglobin F (Human) pAb

Code No. PM078

Anti-Hemoglobin F (Human) pAb

Price

¥60,000

Availability (in Japan)

10 or more

(In Japan at 17:00,
Nov 14, 2019 in JST)

Size

100 µL

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Rabbit Ig (aff.)
Applications
IH
1:100 (paraffin section)  
Immunogen (Antigen) KLH conjugated synthetic peptide, CLTSLGDAIKH (corresponding to amino acid residues 69-78 of human hemoglobin, gamma A)
Reactivity [Gene ID]

Human[3047]

Storage buffer PBS/1% BSA/0.09% NaN3
Storage temp. 4°C Conjugate Unlabeled Manufacturer MBL
Alternative names Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1, HbF
Background Human hemoglobin is consists from heterotetramer of two alpha chains and two non-alpha chains,and each poly peptide chain binds one heme. 3 types of hemoglobin, HbA(α2β2), HbA2(α2δ2) and HbF(α2γ2), presents in normal adults. The synthesis of HemoglobinA(HbA) increases after the birth , whereas Hemoglobin F (HbF) rapidly declines to extremely about 1% or less of the whole by the age of 1 year. HbF-containing cells are minor erythrocytes in normal adults, however, detects in fetus and in patients with aplastic anemia, MDS,hemoglobinopathies, and malignancies affecting the erythropoietic system.
Related products 169A Anti-Hemoglobin A (Human) pAb
References
  1. Choi JW et al. A new anti-hemoglobin F antibody against synthetic peptides for the detection of F-cell precursors (F-blasts) in bone marrow. Int J Hematol. 74, 277-80 (2001)(PMID: 11721963
  2. Choi JW et al. Hemoglobin F synthesis is not restricted to fetal erythropoietic organs during extramedullary hematopoiesis. Heamatologica 87, 323-5 (2002)(PMID: 11869947
  3. Choi JW et al. F-blast is a useful marker for differentiating hypocellular refractory anemia from aplastic anemia. Int J Hematol. 75, 257-60 (2002)(PMID: 11999352
  4. Choi JW et al.  Significance of fetal hemoglobin-containing erythroblasts (F blasts) and the F blast/F cell ratio in myelodysplastic syndromes. Leukemia 16, 1478-83 (2002)(PMID: 12145688
  5. Choi JW et al. F blast production correlates strongly with upregulation of inducible nitric oxide synthase in myelodysplastic syndromes. Annals Hematol.  81, 548-50 (2002)(PMID: 12373361
Product category
Research area
Cancer
Tools
Molecular pathology tools
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  • The availability is based on the information in Japan at 17:00, Nov 14, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.