Antibody detailed product information

Code No. PM078
Anti-Hemoglobin F (Human) pAb
Price ¥60,000
Size 100 µL
Availability (in Japan) 10 or more
（In Japan at 17:00, Apr 20, 2024 in JST）
Clonality Polyclonal
Clone Polyclonal
Isotype
(Immunized Animal) 		Rabbit Ig (aff.)
Applications IH　1:100 (paraffin section)  
Immunogen
(Antigen)		 KLH conjugated synthetic peptide, CLTSLGDAIKH (corresponding to amino acid residues 69-78 of human hemoglobin, gamma A)
Reactivity [Gene ID]

Human[3047]
Storage buffer PBS/1% BSA/0.09% NaN3
Storage temp. 4°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1, HbF
Background Human hemoglobin is consists from heterotetramer of two alpha chains and two non-alpha chains,and each poly peptide chain binds one heme. 3 types of hemoglobin, HbA(α2β2), HbA2(α2δ2) and HbF(α2γ2), presents in normal adults. The synthesis of HemoglobinA(HbA) increases after the birth , whereas Hemoglobin F (HbF) rapidly declines to extremely about 1% or less of the whole by the age of 1 year. HbF-containing cells are minor erythrocytes in normal adults, however, detects in fetus and in patients with aplastic anemia, MDS,hemoglobinopathies, and malignancies affecting the erythropoietic system.
Product category Research area:Cancer
References
  1. Choi JW et al. A new anti-hemoglobin F antibody against synthetic peptides for the detection of F-cell precursors (F-blasts) in bone marrow. Int J Hematol. 74, 277-80 (2001)（PMID: 11721963）
  2. Choi JW et al. Hemoglobin F synthesis is not restricted to fetal erythropoietic organs during extramedullary hematopoiesis. Heamatologica 87, 323-5 (2002)（PMID: 11869947）
  3. Choi JW et al. F-blast is a useful marker for differentiating hypocellular refractory anemia from aplastic anemia. Int J Hematol. 75, 257-60 (2002)（PMID: 11999352）
  4. Choi JW et al.  Significance of fetal hemoglobin-containing erythroblasts (F blasts) and the F blast/F cell ratio in myelodysplastic syndromes. Leukemia 16, 1478-83 (2002)（PMID: 12145688）
  5. Choi JW et al. F blast production correlates strongly with upregulation of inducible nitric oxide synthase in myelodysplastic syndromes. Annals Hematol.  81, 548-50 (2002)（PMID: 12373361）
  • The availability is based on the information in Japan at 17:00, Apr 20, 2024 in JST.
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  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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