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HOME > Product search results > Code No. PM033 Anti-IL-33 (Human) pAb

Code No. PM033

Anti-IL-33 (Human) pAb

Price

¥48,000

Availability (in Japan)

1-9

(In Japan at 00:05,
Jan 20, 2020 in JST)

Size

100 µL

Data
  • Western Blotting

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Rabbit Ig (aff.)
Applications
WB
1:200  
IC*
reported.  (PMID: 22460292
IH
1:500-1:1,000 (Heat treatment is necessary for paraffin embedded sections.)  
Immunogen (Antigen) Recombinant Human full length IL-33 (270 a.a.)
Reactivity [Gene ID]

Human[90865]

Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Background Interleukin-1 (IL-1) family, such as IL-1a/b and IL-18, have important functions in host defense, immune regulation, and inflammation. IL-33, a member of the IL-1 family, that shows to induce T helper (Th) type 2 responses by signaling through the IL-1 receptor-related protein ST2 (IL-1R4), an orphan member of the IL-1 receptor family. Similarly to IL-1α/β and IL-18, IL-33 is synthesized as a 31 kDa precursor protein has been shown to be cleaved by caspase-1 in vitro. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 has been originally identified as NF-HEV, which is a nuclear factor preferentially expressed in high endothelial venules. IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor involved in transcriptional regulation.
Related products 7650 Human IL-33 Cytokine domain Detection Kit
M161-3 Anti-IL-33 (Mouse) mAb
D358-3 Anti-IL-38 (IL1F10) (Human) mAb
D359-3 Anti-IL-38 (IL1F10) (Human) mAb
Citations

Western Blotting

  1. Nomura K et al. Regulation of interleukin-33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines. Laryngoscope 122, 1185-92 (2012)(PMID:22460292)

Immunocytochemistry

  1. Nomura K et al. Regulation of interleukin-33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines. Laryngoscope 122, 1185-92 (2012)(PMID:22460292)

Immunohistochemistry

  1. Matsuda A et al. The role of interleukin-33 in chronic allergic conjunctivitis. Invest Ophthalmol Vis Sci. 50, 4646-52 (2009)(PMID:19458329)
  2. Guo Z et al. IL-33 promotes airway remodeling and is a marker of asthma disease severity. J Asthma. 51, 863-9 (2014)(PMID:24796648)
  3. Abe K et al. Interleukin-33/ST2-Mediated Inflammation Plays a Critical Role in the Pathogenesis and Severity of Type I Autoimmune Hepatitis. Hepatol Commun. 3, 670-684 (2019)(PMID:31061955)
Product category
Research area
Immunology
Cytokine & Growth Factors
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  • The availability is based on the information in Japan at 00:05, Jan 20, 2020 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.