Code No. | PM033 | |
Anti-IL-33 (Human) pAb | ||
Price | ¥52,800 | |
Size | 100 µL | |
Availability (in Japan) | 10 or more
(In Japan at 00:05, Apr 20, 2024 in JST) |
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Clonality | Polyclonal | |
Clone | Polyclonal | |
Isotype (Immunized Animal) |
Rabbit Ig (aff.) | |
Applications | WB 1:500 IC* reported. (PMID: 22460292) IH 1:500-1:1,000 (Heat treatment is necessary for paraffin embedded sections.) IF* reported. (PMID: 33098728) |
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Immunogen (Antigen) |
Recombinant Human full length IL-33 (270 a.a.) | |
Reactivity [Gene ID] | Human[90865] |
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Storage buffer | PBS/50% glycerol, pH 7.2 | |
Storage temp. | -20°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Background | Interleukin-1 (IL-1) family, such as IL-1a/b and IL-18, have important functions in host defense, immune regulation, and inflammation. IL-33, a member of the IL-1 family, that shows to induce T helper (Th) type 2 responses by signaling through the IL-1 receptor-related protein ST2 (IL-1R4), an orphan member of the IL-1 receptor family. Similarly to IL-1α/β and IL-18, IL-33 is synthesized as a 31 kDa precursor protein has been shown to be cleaved by caspase-1 in vitro. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 has been originally identified as NF-HEV, which is a nuclear factor preferentially expressed in high endothelial venules. IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor involved in transcriptional regulation. | |
Related products | M161-3 Anti-IL-33 (Mouse) mAb D358-3 Anti-IL-38 (IL1F10) (Human) mAb D359-3 Anti-IL-38 (IL1F10) (Human) mAb |
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Product category | Research area:Immunology Cytokine & Growth Factors | |
Data | ||
Citations | Western Blotting
Immunocytochemistry
Immunohistochemistry
Immunofluorescence
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