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HOME > Product search results > Code No. D360-3 Anti-Mincle (Human) mAb (Functional Grade)

Code No. D360-3

Anti-Mincle (Human) mAb (Functional Grade)

Price

¥72,000

Availability (in Japan)

1-9

(In Japan at 17:00,
Aug 14, 2020 in JST)

Size

100 µg/100 µL

Data
  • Flow Cytometry

  • Function

Clonality Monoclonal Clone 1H2
Isotype (Immunized Animal) Rat IgG2bκ
Applications
FCM
1-5 µg/mL  
Function
1 µg/mL for inhibition assay  (PMID: 24733387
Immunogen (Antigen) Human Mincle expressed 293T transfectants
Reactivity [Gene ID]

Human[26253]

Storage buffer 1 mg/mL in PBS. Azide free, 0.22 μm sterile-filtered
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names CLEC4E, CLECSF9, C-type lectin domain family 4. member E
Background 結核菌の細胞壁表層にはミコール酸含有脂質および糖脂質が存在し、宿主受容体との接点として働きます。トレハロースジミコール酸(TDM)は、強いアジュバント活性を有するミコール酸含有糖脂質であり、TDMの自然免疫受容体としてMincleが同定されました。Mincleは、マクロファージ、樹状細胞、好中球の細胞表面に発現し、リガンドが結合すると、FcRγと共役して細胞内にシグナル伝え、NF-κBやNFATのような転写因子を活性化し、炎症性サイトカイン産生を誘導します。
Related products D266-3 Anti-Mincle (Mouse) mAb
D266-3M2 Anti-Mincle (Mouse) mAb (Functional Grade)
D266-6 Anti-Mincle (Mouse) mAb-Biotin
D292-3 Anti-Mincle (Mouse) mAb
D292-3M2 Anti-Mincle (Mouse) mAb (Functional Grade)
D316-3 Anti-Mincle (Guinea pig) mAb
M090-3 Rat IgG2b (isotype control)
Citations

Function

  1. Hattori Y et al. Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle. J Biol Chem. 289, 15405-12 (2014)(PMID:24733387)
  2. Tomita Y et al. Induction of tumor-specific CD8+ cytotoxic T lymphocytes from naïve human T cells by using Mycobacterium-derived mycolic acid and lipoarabinomannan-stimulated dendritic cells. Cancer Immunol Immunother. 68, 1605-1619 (2019)(PMID:31531696)
Product category
Research area
Immunology
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 17:00, Aug 14, 2020 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.