Anti-Aggrus (Podoplanin) (Mouse) mAb

Price

¥52,800

Availability (in Japan)

10 or more

（In Japan at 17:00,
Dec 13, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Western Blotting Immunoprecipitation Flow Cytometry Immunohistochemistry
Clonality	Monoclonal	Clone	8F11
Isotype (Immunized Animal)	Rat IgG2a
Applications	WB 1 µg/mL IP 1-2 µg/250 µL of cell extract from 2.5 x 10⁶ cells FCM 5-10 µg/mL (final concentration) IC* reported. （PMID: 18924607） IH 1.25 µg/mL (whole mount)
Immunogen (Antigen)	NL-17 cell membrane fraction
Reactivity [Gene ID]	Mouse[14726]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	Pdpn, T1a, Gp38, OTS-8, T1alpha, RANDAM-2, T1-alpha, PA2.26 antigen, glycoprotein 38, transmembrane glycoprotein E11
Background	In addition to hemostasis and host defense, platelets are involved in the induction of inflammation, tissue repair, and tumor metastasis. Aggrus (T1α/Podoplanin) is a novel 36-45 kDa membrane sialoglycoprotein that induces platelet aggregation. Aggrus is highly expressed in various tumor cells and the platelet aggregation ability of Aggrus depends on specific oligosaccharide structures that may be related to the metastasis process in cancer cells. Aggrus has been identified as a diagnostic tumor marker for seminomas and testicular cancers.
Related products	D321-A48 Anti-Podoplanin (Mouse) mAb -Alexa Fluor™ 488 D321-3 Anti-Podoplanin (Mouse) mAb
Citations	Western Blotting Chida J et al. Prion protein protects mice from lethal infection with influenza A viruses. PLoS Pathog. 14, e1007049 (2018)(PMID:29723291) Kadowaki H et al. Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1. Sci Rep. 8, 7317 (2018)(PMID:29743537) Chida J et al. Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice. PLoS Pathog. 16, e1008823 (2020)(PMID:32845931) Flow Cytometry Lapinski PE et al. RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. J Clin Invest. 122, 733-47 ((2012)(PMID:22232212) Immunocytochemistry Fu J et al. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest. 118, 3725-37 (2008)(PMID:18924607) Immunohistochemistry Kallert SM et al. Replicating viral vector platform exploits alarmin signals for potent CD8⁺ T cell-mediated tumour immunotherapy. Nat Commun. 8, 15327 (2017)(PMID:28548102) Chida J et al. Prion protein protects mice from lethal infection with influenza A viruses. PLoS Pathog. 14, e1007049 (2018)(PMID:29723291)
Product category	Research area Cancer Cell surface antigens

The availability is based on the information in Japan at 17:00, Dec 13, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.