Anti-Synaptophysin mAb

Price

¥48,000

Availability (in Japan)

10 or more

（In Japan at 17:00,
Aug 13, 2020 in JST）

Size

100 µg/100 µL

Citations

Data Sheet

SDS

Data	Western Blotting
Clonality	Monoclonal	Clone	171B5
Isotype (Immunized Animal)	Mouse IgG1
Applications	WB 1 µg/mL IC* reported. （PMID: 19222710） IH 10 µg/mL
Immunogen (Antigen)	purified synaptic vesicle fraction from guinea pig cerebrum
Reactivity [Gene ID]	Human[6855], Mouse[20977], Rat*[24808](PMID: 19222710/20609425)
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	SYP, MRXSYP
Background	Synaptophysin (also named as SVP38 and p38) is an acidic Ca²⁺ binding glycoprotein of about 38 kDa which exist largely in synaptic vesicles. It has 4 transmembrane regions and reported that it is a major cholesterol-binding protein in synaptic vesicles. Synaptophysin may regulate synaptic exocytosis by competing with proteins such as SNAP25 and syntaxins for binding synaptobrevin (vesicle-associated membrane protein, or VAMP). It may also participate in synaptic endocytosis, which contributes to rapid recycling of synaptic vesicle.
Related products	D029-3 Anti-Drebrin mAb M068-3 Anti-Apolipoprotein E (Human) mAb M067-3 Anti-Apolipoprotein E4 (Human) mAb D097-3 Anti-GFAP (Glial Fibrillary Acidic Protein) mAb
Citations	Western Blotting Kojima N et al. Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Neuroscience. 165, 138-150 (2010)(PMID:19837137) Liu Y et al. Disturbances of soluble N-ethylmaleimide-sensitive factor attachment proteins in hippocampal synaptosomes contribute to cognitive impairment after repetitive formaldehyde inhalation in male rats. Neuroscience. 169, 1248-1254 (2010)(PMID:20609425) Immunocytochemistry Mizui T et al. Drebrin E is involved in the regulation of axonal growth through actin-myosin interactions. J Neurochem. 109, 611-622 (2009)(PMID:19222710)
Product category	Research area Neuroscience

The availability is based on the information in Japan at 17:00, Aug 13, 2020 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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