Anti-Synaptophysin mAb

Price

¥48,000

Availability (in Japan)

10 or more

（In Japan at 00:05,
Jul 1, 2022 in JST）

Size

100 µg/100 µL

Citations

Data Sheet

SDS

Data	Western Blotting
Clonality	Monoclonal	Clone	171B5
Isotype (Immunized Animal)	Mouse IgG1
Applications	WB 1 µg/mL IC* reported. （PMID: 19222710） IH 10 µg/mL
Immunogen (Antigen)	purified synaptic vesicle fraction from guinea pig cerebrum
Reactivity [Gene ID]	Human[6855], Mouse[20977], Rat*[24808](PMID: 19222710/20609425)
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	SYP, MRXSYP
Background	Synaptophysin (also named as SVP38 and p38) is an acidic Ca²⁺ binding glycoprotein of about 38 kDa which exist largely in synaptic vesicles. It has 4 transmembrane regions and reported that it is a major cholesterol-binding protein in synaptic vesicles. Synaptophysin may regulate synaptic exocytosis by competing with proteins such as SNAP25 and syntaxins for binding synaptobrevin (vesicle-associated membrane protein, or VAMP). It may also participate in synaptic endocytosis, which contributes to rapid recycling of synaptic vesicle.
Related products	D029-3 Anti-Drebrin mAb M068-3 Anti-Apolipoprotein E (Human) mAb M067-3 Anti-Apolipoprotein E4 (Human) mAb D097-3 Anti-GFAP (Glial Fibrillary Acidic Protein) mAb
Citations	Western Blotting Kojima N et al. Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Neuroscience. 165, 138-150 (2010)(PMID:19837137) Liu Y et al. Disturbances of soluble N-ethylmaleimide-sensitive factor attachment proteins in hippocampal synaptosomes contribute to cognitive impairment after repetitive formaldehyde inhalation in male rats. Neuroscience. 169, 1248-1254 (2010)(PMID:20609425) Immunocytochemistry Mizui T et al. Drebrin E is involved in the regulation of axonal growth through actin-myosin interactions. J Neurochem. 109, 611-622 (2009)(PMID:19222710)
Product category	Research area Neuroscience

The availability is based on the information in Japan at 00:05, Jul 1, 2022 in JST.
The special price is shown in red color.
Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.