Data |
Western Blotting
Immunoprecipitation
Immunocytochemistry
|
Clonality |
Polyclonal
|
Clone |
Polyclonal |
Isotype
(Immunized Animal)
|
Rabbit Ig (aff.)
|
Applications |
- WB
- 1:1,000
- IP
- 5 µL/300 µL of cell extract from 3 x 106 cells
- IC
- 1:200
|
Immunogen
(Antigen) |
KLH conjugated synthetic peptide corresponding to C-terminus of human Lamin B1
|
Reactivity
[Gene ID] |
Human[4001], Mouse[16906], Rat[116685], Hamster[103161362] |
Storage buffer |
PBS/50% glycerol, pH 7.2
|
Storage temp. |
-20°C
|
Conjugate |
Unlabeled |
Manufacturer |
MBL |
Alternative names |
ADLD, LMN, LMN2, LMNB
|
Background |
Lamin B1 is one of the component proteins of the nuclear lamina that is a dense fibrous network and lies on the inner surface of the inner nuclear membrane. The nuclear lamina plays an essential role in chromatin organization, cell cycle regulation, DNA replication, cell differentiation and apoptosis. |
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|
Citations |
Western Blotting - Jia X et al. The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model. Life Sci. 90, 934-43 (2012)(PMID:22569299)
- Jia X et al. Dysregulated bile acid synthesis, metabolism and excretion in a high fat-cholesterol diet-induced fibrotic steatohepatitis in rats. Dig Dis Sci. 58, 2212-22 (2013)(PMID:23824403)
- Yamamoto N et al. Polymerase complex with lysine at position 627 of the PB2 of influenza virus A/Hong Kong/483/97 (H5N1) efficiently transcribes and replicates virus genes in mouse cells. Virus Res. 178, 404-10 (2013)(PMID:24070983)
- Mukai R, Ohshima T. HTLV-1 HBZ positively regulates the mTOR signaling pathway via inhibition of GADD34 activity in the cytoplasm.Oncogene 33, 2317-28 (2014)23708656(PMID:23708656)
- Qu L et al. hCINAP negatively regulates NF-κB signaling by recruiting the phosphatase PP1 to deactivate IKK complex. J Mol Cell Biol. 7, 529-42 (2015)(PMID:26089539)
- Bai D et al. The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth. Nat Commun. 7, 12310 (2016)(PMID:27477389)
- Hirano K, Namihira M. FAD influx enhances neuronal differentiation of human neural stem cells by facilitating nuclear localization of LSD1. FEBS Open Bio. 7, 1932-1942 (2017)(PMID:29226080)
- Mizunoe Y et al. Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways. Redox Biol. 15, 115-124 (2017)(PMID:29241092)
- Kaneko H et al. Taurine is an amino acid with the ability to activate autophagy in adipocytes. Amino Acids. 50, 527-535 (2018)(PMID:29523960)
- Endo H et al. Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells. Sci Rep. 8, 10122 (2018)(PMID:29973599)
- Fujii N et al. Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue. Exp Gerontol. 118, 55-64 (2019)
(PMID:30620889)
- Xu R et al. hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy. Nat Commun. 10, 3812 (2019)(PMID:31444354)
- Mizunoe Y et al. Cathepsin B Overexpression Induces Degradation of Perilipin 1 to Cause Lipid Metabolism Dysfunction in Adipocytes. Sci Rep. 10, 634 (2020)(PMID:31959889)
- Endo H et al. Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment. Redox Biol. 36, 101643 (2020)(PMID:32863227)
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Product category |
- Tools
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