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HOME > Product search results > Code No. M032-3 Anti-Caspase-8 (Human) mAb

Code No. M032-3

Anti-Caspase-8 (Human) mAb



Availability (in Japan)


(In Japan at 17:00,
Aug 6, 2020 in JST)


100 µg/100 µL

  • Western Blotting

Clonality Monoclonal Clone 5F7
Isotype (Immunized Animal) Mouse IgG2bκ
1 μg/mL  
reported.  (PMID: 15701651
Immunogen (Antigen) Recombinant Human Caspase-8 (C-terminal :176-460 a.a.)
Reactivity [Gene ID]

Human[841], Mouse(-)

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names CASP8
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M060-3 Anti-Caspase-5 mAb
M053-3 Anti-Caspase-7 mAb
M058-3 Anti-Caspase-8 (Human) mAb
M054-3 Anti-Caspase-9 mAb

Western Blotting

  1. Eguchi Y et al. ATP-dependent steps in apoptotic signal transduction. Cancer Res. 59, 2174-81 (1999)(PMID:10232605)
  2. Imai Y et al. The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. Nature 398, 777-785 (1999)(PMID:10235259)
  3. Migita K et al. Nitric oxide protects cultured rheumatoid synovial cells from Fas-induced apoptosis by inhibiting caspase-3. Immunology 103, 362-7 (2001)(PMID:11454065)
  4. Nakayama M et al. Multiple pathways of TWEAK-induced cell death. J Immunol. 168, 734-43 (2002)(PMID:11777967)
  5. Imamura R et al. Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha. J Biol Chem. 279, 46415-23 (2004)(PMID:15337758)
  6. Hasegawa M et al. ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP. J Biol Chem. 280, 15122-30 (2005)(PMID:15701651)
  7. Ohgushi M et al. Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells. Mol Cell Biol. 25, 10017-28 (2005)(PMID:16260615)
  8. Okamoto K et al. Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB. Genes Cells 11, 177-91 (2006)(PMID:16436054)
  9. Stagni V et al. ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells. Blood 111, 829-37 (2008)(PMID:17932249)
  10. Inaba S et al. The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells. J Antibiot. 62, 507-12 (2009)(PMID:19590527)
  11. Liu J et al. Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer 10, 95 (2011)(PMID:21801448)
  12. Estornes Y et al. dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death Differ. 19, 1482-94 (2012)(PMID:22421964)
  13. Horie N et al. Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells. Biol Pharm Bull. 28, 574-9 (2005)(PMID:15802789)
  14. Caro-Maldonado A et al. Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells. Cell Death Differ. 17, 1335-44 (2010)(PMID:20203689)
  15. Maas C et al. CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex. Cell Death Dis. 4, e782 (2013)(PMID:23990022)
  16. Orme MH et al. The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles. Nat Commun. 7, 10972 (2016)(PMID:26960254)
  17. Glab JA et al. DR5 and caspase-8 are dispensable in ER stress-induced apoptosis. Cell Death Differ. 24, 944-950 (2017)(PMID:28409774)
  18. Ohsugi T et al. Decreased expression of interferon-induced protein 2 (IFIT2) by Wnt/β-catenin signaling confers anti-apoptotic properties to colorectal cancer cells. Oncotarget 8, 100176-100186 (2017)(PMID:29245969)
  19. Dubuisson A et al. Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization. Cell Death Dis. 10, 101 (2019) (PMID:30718507)


  1. Hasegawa M et al. ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP. J Biol Chem. 280, 15122-30 (2005)(PMID:15701651)
Product category
Research area

  • The availability is based on the information in Japan at 17:00, Aug 6, 2020 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.