Price
¥52,800
Availability (in Japan)
10 or more
(In Japan at 00:05,
Jun 30, 2024 in JST)
Size
100 µL (1 mg/mL)
Data | |||||
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Clonality | Monoclonal | Clone | MabB5 | ||
Isotype (Immunized Animal) | Rat IgG2a | ||||
Applications | |||||
Immunogen (Antigen) | Recombinant | ||||
Reactivity [Gene ID] | Mouse[259277] |
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Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | Klk8, Kallikrein 8, kallikrein related-peptidase 8 | ||||
Background | Neuropsin is a trypsin-type, extracellular, serine protease that was first cloned from mouse limbic brain as a factor related to neural plasticity. Physiological studies indicated that kindling stimulation induced neuropsin mRNA and its protease activity also increased in limbic areas during kindling and long-term potentiation. Subsequent study indicated that neuropsin mRNA localized not only in the limbic brain, but also in developing organs and adult keratinocytes. Recent immunohistochemical analysis demonstrated that neuropsin localized exclusively in the keratinizing epithelia of the epidermis and various stratified mucous membranes. During development, neuropsin was found in the various epithelia at embryonic days 14.5-15.5, prior to formation of the stratum corneum. Much stronger expression of neuropsin is observed in nude mouse skin and mucous membranes than in normal mice. Those studies suggested that neuropsin is related to differentiation of keratinocytes and the process of keratogenesis. | ||||
Citations |
Western Blotting
Neutralization
Immunoprecipitation
Immunocytochemistry
Immunohistochemistry
Function
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Product category |
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