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HOME > Product search results > Code No. D348-3 Anti-Pfetin (Human) mAb

Code No. D348-3

Anti-Pfetin (Human) mAb

Price

¥60,000

Availability (in Japan)

10 or more

(In Japan at 17:00,
Dec 9, 2019 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

  • Immunohistochemistry

Clonality Monoclonal Clone 10-4
Isotype (Immunized Animal) Mouse IgG2bκ
Applications
WB
1 µg/mL  
IH
1 µg/mL  
Immunogen (Antigen) Human Pfetin (recombinant)
Reactivity [Gene ID]

Human[115207](PMID: 19815537)

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names PFET1, PFETIN, C13orf2, KCTD12, potassium channel tetramerization domain containing 12
Background Pfetin (KCTD12, potassium channel tetramerization domain containing was originally discovered in fetal cochlea. Pfetin contains a putative potassium channel domain, and regulates GAVA (B) receptor signaling. Association of pfetin expression with favorable prognosis in gastrointestinal stromal tumor (GIST) was discovered by proteomics. The prognostic values of pfetin were validated in hundreds of GIST cases in multiple cohorts by immunohistochemistry.
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Citations

Immunohistochemistry

  1. Kikuta K et al. Pfetin as a prognostic biomarker in gastrointestinal stromal tumor: novel monoclonal antibody and external validation study in multiple clinical facilities. Jpn J Clin Oncol 40, 60-72 (2010)(PMID:19815537)
  2. Kubota D et al. Pfetin as a prognostic biomarker for gastrointestinal stromal tumor: validation study in multiple clinical facilities. Jpn J Clin Oncol 41, 1194-1202 (2011)(PMID: 21903705)
  3. Kubota D et al. Validation Study on Pfetin and ATP-dependent RNA Helicase DDX39 as Prognostic Biomarkers in Gastrointestinal Stromal Tumour. Jpn J Clin Oncol 42, 730-741 (2012)(PMID:22723667)
References
  1. Resendes BL et al. Isolation from cochlea of a novel human intronless gene with predominant fetal expression. J Assoc Res Otolaryngol 5, 185-202 (2004)
  2. Ivankova K et al. Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12).  J Biol Chem 288, 24848-56 (2013)
  3. Suehara Y et al. Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics. Clin Cancer Res 14, 1707-17 (2008)
  4. Kikuta K et al. Pfetin as a prognostic biomarker in gastrointestinal stromal tumor: novel monoclonal antibody and external validation study in multiple clinical facilities. Jpn J Clin Oncol 40, 60-72 (2010)
  5. Kubota D et al. Pfetin as a prognostic biomarker for gastrointestinal stromal tumor: validation study in multiple clinical facilities. Jpn J Clin Oncol 41, 1194-1202 (2011)
  6. Kubota D et al. Validation Study on Pfetin and ATP-dependent RNA Helicase DDX39 as Prognostic Biomarkers in Gastrointestinal Stromal Tumour.  Jpn J Clin Oncol. 42, 730-41 (2012)
  7. Kondo T et al. Proteomic approach toward personalized sarcoma treatment: lessons from prognostic biomarker discovery in gastrointestinal stromal tumor.  Proteomics Clin Appl 7, 70-8 (2013) 
Product category
Cancer
Research area
Cancer
Tools
Molecular pathology tools
Brands
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  • The availability is based on the information in Japan at 17:00, Dec 9, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.