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HOME > Product search results > Code No. D316-3 Anti-Mincle (Guinea pig) mAb

Code No. D316-3

Anti-Mincle (Guinea pig) mAb

Price

¥48,000

Availability (in Japan)

10 or more

(In Japan at 00:05,
Dec 16, 2019 in JST)

Size

100 µg/100 µL

Data
  • Flow Cytometry

Clonality Monoclonal Clone 5H4
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
FCM
1-10 µg/mL for 5x 105 cells  
Immunogen (Antigen) 2B4 T cell hybridoma expressing full length of guinea pig Mincle
Reactivity [Gene ID]

Guinea pig[100726838]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names C-type lectin domain family 4 member E, Clec4e, Clecsf8
Background Macrophage-inducible C-type lectin (Mincle, also called as Clec4e and Clecsf9), a type II transmembrane C-type lectin receptor, is expressed mainly in macrophages. Mincle is selectively associated with the Fc receptor common g chain which contains immunoreceptor tyrosine-based activation motif (ITAM) and activates macrophages to produce inflammatory cytokines and chemokines. Mincle expressing cells are activated by spliceosome associated protein 130 (SAP130) released from dead cells. Recently, Mincle is reported to recognize Mycobacterium tuberculosis as well as pathogenic fungus Malassezia species. Mincle is demonstrated to be an essential receptor for a mycobacterial glycolipid, trehalose-6,6’-dimycolate (TDM). The cytokine/chemokine production of macrophages which Malassezia or M.tuberculosis induces in Mincle-/- mice is significantly impaired. Mincle is considered to play a crucial role in immune responses to these ligands.
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D360-3 Anti-Mincle (Human) mAb (Functional Grade)
D266-6 Anti-Mincle (Mouse) mAb-Biotin
Citations

Flow Cytometry

  1. Toyonaga K et al. Characterization of the receptors for mycobacterial cord factor in guinea pig. PLoS One 9, e88747 (2014)(PMID:24533147)
Product category
Research area
Immunology
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  • The availability is based on the information in Japan at 00:05, Dec 16, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.