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HOME > Product search results > Code No. D223-3 Anti-Reelin (CR-50) mAb

Code No. D223-3

Anti-Reelin (CR-50) mAb

Price

¥48,000

Availability (in Japan)

1-9

(In Japan at 00:05,
Nov 17, 2019 in JST)

Size

100 µg/100 µL

Data
  • Immunohistochemistry

Clonality Monoclonal Clone RE-3B9(R3B9)
Isotype (Immunized Animal) Mouse IgG1
Applications
IP*
reported.  (PMID: 8987733
IC*
reported.  (PMID: 10920200
IH
2-10 µg/mL (Can be used in cryosections.)  
Function*
Interference of reelin aggregation and blockade of its function.  (PMID: 10920200 / 10880570 / 9223338
Immunogen (Antigen) homogenates of normal embryonic brain
Reactivity [Gene ID]

Mouse[19699]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names Reln, reelin, rl, reeler
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D351-3 Anti-Reelin (Mouse) mAb
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Citations

Immunoprecipitation

  1. D'Arcangelo G et al. Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J Neurosci. 17, 23-31 (1997)(PMID:8987733)
  2. Kohno T et al. Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis. J Neurosci. 35, 4776-87 (2015)(PMID:25788693)

Immunocytochemistry

  1. Utsunomiya-Tate N et al. Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody. PNAS 97, 9729-34 (2000)(PMID:10920200)
  2. Zhang X et al. Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell. in press(PMID:30796637)

Immunohistochemistry

  1. Ogawa M et al. The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron 14, 899-912 (1995)(PMID:7748558)
  2. Rice DS et al. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development. 125, 3719-29 (1998)(PMID:9716537)
  3. Nichols AJ, Olson EC. Reelin promotes neuronal orientation and dendritogenesis during preplate splitting. Cereb Cortex. 20, 2213-23 (2010)(PMID:20064940)
  4. Wierenga CJ et al. Molecular and electrophysiological characterization of GFP-expressing CA1 interneurons in GAD65-GFP mice. PLoS One 5, e15915 (2010)(PMID:21209836)
  5. Jiang Y et al. Ndel1 and Reelin Maintain Postnatal CA1 Hippocampus Integrity. J Neurosci. 36, 6538-52 (2016)(PMID:27307241)

Function

  1. Ogawa M et al. The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron 14, 899-912 (1995)(PMID:7748558)
  2. Del Rio JA, et al. A role for Cajal-Retzius cells and reelin in the development of hippocampal connections. Nature 385, 70-4 (1997)(PMID:8985248)
  3. Miyata T et al. Regulation of Purkinje cell alignment by reelin as revealed with CR-50 antibody. J Neurosci. 17, 3599-609 (1997)(PMID:9133383)
  4. Nakajima K et al. Disruption of hippocampal development in vivo by CR-50 mAb against reelin. PNAS 94, 8196-201 (1997)(PMID:9223338)
  5. Utsunomiya-Tate N et al. Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody. PNAS 97, 9729-34 (2000)(PMID:10920200)
  6. Yip JW et al. Reelin controls position of autonomic neurons in the spinal cord. PNAS 97, 8612-6 (2000)(PMID:10880573)
  7. Courtès S et al. Reelin controls progenitor cell migration in the healthy and pathological adult mouse brain. PLoS One 6, e20430 (2011)   (PMID:21647369)
  8. Cuchillo-Ibáñez I et al. Heteromers of amyloid precursor protein in cerebrospinal fluid. PLoS One 8, e72297 (2013)(PMID:25573162)
  9. Bodea GO et al. Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. PLoS One 8, e72297 (2013)(PMID:24449842)
  10. Lin L et al. Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin β1 signaling and STAT3. Oncotarget 7, 9844-58 (2016)(PMID:26848618)
  11. Lin L et al. Reelin promotes adhesion of multiple myeloma cells to bone marrow stromal cells via integrin β1 signaling.  J Cancer.  8, 2212-2222 (2017)(PMID:28819423)
Product category
Research area
Neuroscience
Brands
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  • The availability is based on the information in Japan at 00:05, Nov 17, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
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