Data |
Flow Cytometry
|
Clonality |
Monoclonal
|
Clone |
mNI-11 |
Isotype
(Immunized Animal)
|
Mouse IgG1
|
Applications |
- FCM
- 20 μL (Ready for use.)
|
Immunogen
(Antigen) |
LPS-stimulated U937
|
Reactivity
[Gene ID] |
Human[22918] |
Storage buffer |
PBS/1% BSA/0.09% NaN3
|
Storage temp. |
冷蔵
|
Conjugate |
PE |
Manufacturer |
MBL |
Alternative names |
C1qRp
|
Background |
CD93, also known as C1qRp, is a 100-125 kDa type I membrane protein that is a receptor for the complement protein C1q. CD93 has also been shown to act as a receptor for mannose-binding lectin and surfactant protein A. CD93 is expressed on the surface of monocytes, granulocytes, and endothelial cells, and expression is increased by TNF-α or GM-CSF. CD93 is involved in ligand-mediated enhancement of phagocytosis and intercellular adhesion. |
Related products |
D198-3 Anti-CD93 (Human) mAb
|
References |
- Ikewaki N et al. Unique properties of cluster of differentiation 93 in the umbilical cord blood of neonates. Microbiol Immunol. 57, 822-32 (2013) (PMID:24033555)
- Ikewaki N et al. Flow cytometric identification of CD93 expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood. J Clin Immunol.30, 723-733 (2010) (PMID:20512406)
- Ikewaki N et al. Decrease in CD93 (C1qRp) expression in a human monocyte-like cell line (U937) treated with various apoptosis-inducing chemical substances. Microbiol Immunol. 51, 1189-200 (2007) (PMID: 18094537)
- Ikewaki N et al. Regulation of CD93 cell surface expression by protein kinase C isoenzymes. Microbiol Immunol. 50, 93-103 (2006) (PMID:16490927)
- McGreal EP et al. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. J Immunol. 168, 5222-32 (2002) (PMID:11994479)
- Ikewaki N et al. A unique monoclonal antibody mNI-11 rapidly enhances spread formation in human umbilical vein endothelial cells. J Clin immunol. 20, 317-24 (2000) (PMID:10939719)
- Ikewaki N, Inoko H. Development and characterization of a novel monoclonal antibody (mNI-11) that induces cell adhesion of the LPS-stimulated human monocyte-like cell line U937. J Leukoc Biol. 59, 697-708 (1996) (PMID:8656055)
- Nativel B et al. CD93 is a cell surface lectin receptor involved in the control of the inflammatory response stimulated by exogenous DNA. Immunology. 158, 85-93 (2019)(PMID: 31335975)
|
Product category |
- Research area
- Cell surface antigens
|