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HOME > Product search results > Code No. D028-5 Anti-CD66c (KOR-SA3544) (Human) mAb-PE

Code No. D028-5

Anti-CD66c (KOR-SA3544) (Human) mAb-PE

Price

¥40,000

Availability (in Japan)

10 or more

(In Japan at 17:00,
Dec 11, 2019 in JST)

Size

1 mL (50 tests)

Clonality Monoclonal Clone KOR-SA3544
Isotype (Immunized Animal) Mouse IgG1
Applications
FCM
20 µL (Ready for use.)  
Immunogen (Antigen) cell line (KOCL-22) established from bone marrow blood of patient with congenital leukemia
Reactivity [Gene ID]

Human[4680]

Storage buffer PBS/1% BSA/0.09% NaN3
Storage temp. 4°C Conjugate PE Manufacturer MBL
Alternative names CEACAM6, NCA, CEAL
Background

This monoclonal antibody (clone KOR-SA3544) was reactive with a surface antigen expressed on Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL) without exception (26/26 cases). The recognized antigen is a nonspecific cross-reacting antigen (NCA)-50/90 (CD66c), one of the carcinoembryonic antigen (CEA)-related glycoproteins encoded by a member of the CEA gene family. The Philadelphia chromosome (Ph1) has been implicated as the causative factor in greater than 90% of chronic myelogenous leukemia (CML), in 25-30% of adult and 2-10% of childhood acute lymphoblastic leukemia (ALL) and in rare cases of acute myelogenous leukemia (AML). The presence of the Ph in leukemic cells of ALL patients usually indicates poor prognosis and high risk. Sequential monitoring of the Ph in ALL correlates with the activity of malignant clones and predicts impending clinical relapse, and therefore is useful in guiding clinical therapeutic decisions.

 

Related products D028-3 Anti-CD66c (KOR-SA3544) (Human) mAb
D028-4 Anti-CD66c (KOR-SA3544) (Human) mAb-FITC
Product category
Cancer
Research area
Cancer
Cell surface antigens
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  • The availability is based on the information in Japan at 17:00, Dec 11, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.