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HOME > Product search results > Code No. CY-P1043 Anti-PKR/EIF2AK2 (Human) pAb

Code No. CY-P1043

Anti-PKR/EIF2AK2 (Human) pAb

Price

¥40,000

Special price

¥28,000

(ends 2020/03/31)

 > 

Availability (in Japan)

0
(Contact us)

(In Japan at 00:05,
Jan 20, 2020 in JST)

Size

100 µg

Data
  • Immunoprecipitation

    Time course of poly I:C effect on the kinase activity of PKR in HepG2 cell, measured by IP-kinase aaasay using CycLex PKR/EIF2AK2 Kinase Assay Kit (Cat#CY-1184) and the human PKR/EIF2AK2 rabbit polyclonal antibody (Cat#CY-P1043)

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Rabbit IgG
Applications
IP
IP-kinase assay: 1-2 μg/sample.  
ELISA
  
Immunogen (Antigen) A synthetic peptides corresponding to middle region of human PKR
Reactivity [Gene ID]

Human[5610]

Storage buffer 20 mM phosphate buffer (pH 7.5), 300 mM NaCl, 50 % glycerol
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Background The double-stranded RNA-activated protein kinase (PKR), also known as eukaryotic translation
initiation factor 2-alpha kinase 2 (EIF2AK2), is a ubiquitously expressed serine/threonine protein
kinase that plays a key role in the innate immunity response to viral infection in higher eukaryotes
and has also been implicated in several cellular signal transduction pathways. PKR also has been implicated in regulating other cellular functions such as differentiation, transcription, signal transduction, cell growth and apoptosis in the event of virus infection and other forms of cellular stress. It was reported that the activation of PKR in adipose and liver tissue is caused by obesity. In the absence of PKR, metabolic deterioration due to excess energy or nutrition is alleviated. These findings demonstrate that PKR is an important component of inflammation complex that responds to nutrients and organelle dysfunction.
Related products CY-SPP80 PKR/EIF2AK2 (Human), Active
Product category
Research area
Drug discovery
Signal transduction
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  • The availability is based on the information in Japan at 00:05, Jan 20, 2020 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.