CycLex® brand products are focused on research of novel genes related to drug discovery. Its main target field is protein kinase, protein phosphatase, acetylation/deacetylation, and protein modification.
There are variety of products; kits, antibodies, and enzymes.
CircuLex™ brand products are focused on assay kits for detecting disease-related markers. For example, lipid metabolism, adipocytokine/inflammation, S100 family proteins, and so on.
There are variety of products; kits, antibodies, and recombinant proteins.
*CycLex Co., Ltd. was merged into Medical & Biological Laboratories Co., Ltd. (MBL) as of January 1, 2016
It has been thought that PCSK9 exerts its role in cholesterol metabolism through posttranslational down-regulation of LDLR, the receptor responsible for clearing plasma LDL-C. This hypothesis is consistent with a secreted form of PCSK9 bound directly to the first epidermal growth factor-like repeat (EGF-A) of LDLR and resulting in degradation of the receptor. PCSK9 appears to be an attractive drug target for lowering LDL-C.