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CycLex® Brand/CircuLex Brand.

CycLex® brand products are focused on research of novel genes related to drug discovery. Its main target field is protein kinase, protein phosphatase, acetylation/deacetylation, and protein modification.
There are variety of products; kits, antibodies, and enzymes.


CircuLex brand products are focused on assay kits for detecting disease-related markers. For example, lipid metabolism, adipocytokine/inflammation, S100 family proteins, and so on.
There are variety of products; kits, antibodies, and recombinant proteins.


*CycLex Co., Ltd. was merged into Medical & Biological Laboratories Co., Ltd. (MBL) as of January 1, 2016

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It has been thought that PCSK9 exerts its role in cholesterol metabolism through posttranslational down-regulation of LDLR, the receptor responsible for clearing plasma LDL-C. This hypothesis is consistent with a secreted form of PCSK9 bound directly to the first epidermal growth factor-like repeat (EGF-A) of LDLR and resulting in degradation of the receptor. PCSK9 appears to be an attractive drug target for lowering LDL-C.

Human PCSK9 ELISA Kit  Mouse/Rat PCSK9 ELISA Kit 
PCSK9-LDLR in vitro Binding Assay Kit 

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Cyclex Brand

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Circulex Brand