Price
¥52,800
Availability (in Japan)
1-9
(In Japan at 17:00,
Apr 26, 2024 in JST)
Size
100 µL
Data | |||||
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Clonality | Polyclonal | Clone | Polyclonal | ||
Isotype (Immunized Animal) | Rabbit Ig (aff.) | ||||
Applications |
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Immunogen (Antigen) | Recombinant Mouse p27kip1 | ||||
Reactivity [Gene ID] | |||||
Storage buffer | PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | CDKN1B | ||||
Background | Cyclin dependent kinase inhibitory protein 1 (Kip1) is a 27 kDa inducible inhibitor of cyclin-dependent kinase complexes (CKI). It acts by suppressing S-phase entry and thereby blocking cell cycle progression. Kip1 interacts strongly with D-type cyclins in complex with Cdk4 and weaklier with cyclin E/Cdk2 complex to cause G1 arrest. Kip1 is a potent tumor suppressor for multiple epithelially derived neoplasias, and expression of Kip1 is frequently down regulated in human tumors. Kip1 levels are regulated by phosphorylation and degradation via the ubiquitin-proteosome pathway. | ||||
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