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HOME > Product search results > Code No. D350-3 Anti-PS/PT (Human) mAb

Code No. D350-3

Anti-PS/PT (Human) mAb

Availability (in Japan)

0
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Size

100 µg/100 µL

Data
  • ELISA

  • ELISA

Clonality Monoclonal Clone 231D
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
ELISA
LA test : 6.25~50 µg/mL        PS/PT ELISA : 1:10201  
Immunogen (Antigen) human prothrombin
Reactivity [Gene ID]

Human[2147]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Background Antiphospholipid antibodies (aPL) are immunoglobulins that are related to diverse clinical phenomena, such as arterial and venous thrombosis, complications of pregnancy, livedo reticularis, valvular disease, neurologic disorders, and thrombocytopenia. The term antiphospholipid syndrome (APS) is used to link thrombosis or pregnancy morbidity to the persistence of aPL as one of the most common causes of acquired thrombophilia. Antibodies against phosphatidylserine/prothrombin complex (anti-PS/PT) are highly associated with the APS, and are the major autoantibodies responsible for lupus anticoagulant (LA) activity.        Antibodies included in this reagents recognize PS/PT complex and have LA activity in human plasma, so cloud be useful for study of LA.
References
  1. Sakai Y et al. The effects of phosphatidylserine-dependent antiprothrombin antibody on thrombin generation. Arthritis Rheum. 60, 2457-67 (2009) (PMID:19644870)
Product category
Research area
Immunology
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  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
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