Antibody detailed product information

Code No.	D350-3
Anti-PS/PT (Human) mAb
Size	100 µg/100 µL
Availability (in Japan)	10 or more （In Japan at 17:00, Apr 18, 2024 in JST）
Clonality	Monoclonal
Clone	231D
Isotype (Immunized Animal)	Mouse IgG1 κ
Immunogen (Antigen)	human prothrombin
Reactivity [Gene ID]	Human[2147]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Background	Antiphospholipid antibodies (aPL) are immunoglobulins that are related to diverse clinical phenomena, such as arterial and venous thrombosis, complications of pregnancy, livedo reticularis, valvular disease, neurologic disorders, and thrombocytopenia. The term antiphospholipid syndrome (APS) is used to link thrombosis or pregnancy morbidity to the persistence of aPL as one of the most common causes of acquired thrombophilia. Antibodies against phosphatidylserine/prothrombin complex (anti-PS/PT) are highly associated with the APS, and are the major autoantibodies responsible for lupus anticoagulant (LA) activity. Antibodies included in this reagents recognize PS/PT complex and have LA activity in human plasma, so cloud be useful for study of LA.
Product category	Research area:Immunology
References	Sakai Y et al. The effects of phosphatidylserine-dependent antiprothrombin antibody on thrombin generation. Arthritis Rheum. 60, 2457-67 (2009) (PMID:19644870)

The availability is based on the information in Japan at 17:00, Apr 18, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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