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HOME > Product search results > Code No. PD047 Anti-TLR8 (CD288) (Human) pAb

Code No. PD047

Anti-TLR8 (CD288) (Human) pAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Oct 19, 2017 in JST)

Size

100 µL

Data
  • Western Blotting

  • Western Blotting

  • Flow Cytometry

  • Flow Cytometry

  • Immunocytochemistry

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Rabbit Ig (aff.)
Applications
WB
1:1,000  (PMID: 25297876
FCM
1:100  
IC
1:100  (PMID: 25297876
Reactivity [Gene ID]

Human[51311]

Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names toll-like receptor 8
Background  Toll-like receptor 8 (TLR8) is a pattern recognition receptor that recognizes ssRNA and synthetic imidazoquinoline derivatives. In humans, TLR8 is expressed in myeloid cells, including monocytes, neutrophils, macrophages and myeloid DCs, and in regulatory T cells. TLR8 localizes to the early/late endosomes as a cleaved/associated form of receptor. TLR8 recognizes viral GU-rich ssRNA and endogenous RNA, such as microRNAs, resulting in the production of proinflammatory cytokines but not type I IFNs.
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Citations

Western Blotting

  1. Ishii N et al. Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells. J Immunol. 193, 5118-28 (2014)(PMID:25297876)

Immunocytochemistry

  1. Ishii N et al. Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells. J Immunol. 193, 5118-28 (2014)(PMID:25297876)
References
  1. Itoh H et al.  UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling. PLos ONE  6, e28500 (2011)
Product category
Research area
Immunology
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Oct 19, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.