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HOME > Product search results > Code No. D236-3 Anti-RUNX3 mAb

Code No. D236-3

Anti-RUNX3 mAb

Availability (in Japan)

1-9

(In Japan at 00:05,
Dec 14, 2018 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

  • Immunohistochemistry

Clonality Monoclonal Clone R3-1E10
Isotype (Immunized Animal) Mouse IgG1
Applications
WB
0.2 μg/mL  
IH
2 μg/mL (Heat treatment is necessary for paraffin embedded sections.)  
Immunogen (Antigen) Human RUNX3 polypeptide
Reactivity [Gene ID]

Human[864], Mouse[12399]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names runt-related transcription factor 3; AML2; CBFA3; PEBP2aC
Background The Runx (runt-related protein) family of transcription factors plays important roles in different tissues and cell lineages. Runx1 determines commitment to the hematopoietic cell lineage and Runx2 determines commitment to the osteoblastic lineage. Runx3 is involved in gastric epithelial growth and differentiation. PEBP2/Cbfb is required for Runx-dependent transcriptional regulation. Runx proteins interact with many other transcription factors and co-regulators in the transcriptional regulation of their target genes.
Related products D234-3 Anti-RUNX3 mAb
D235-3 Anti-RUNX3 mAb
D127-3 Anti-PEBP2β (CBFβ) (Human) mAb
D130-3 Anti-Runx2 (Cbfa1) mAb
D207-3 Anti-Runx mAb
Citations

Western Blotting

  1. Tsuchiya Y et al. Runx3 expression and its roles in mouse endometrial cells. J Reprod Dev. 58, 592-8 (2012)(PMID:22785323)

Immunohistochemistry

  1. Tsunematsu T et al. RUNX3 has an oncogenic role in head and neck cancer. PLoS One 4, e5892 (2009)(PMID:19521519)
  2. Ito K et al. RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell 14, 226-37 (2008)(PMID:18772112)
References
  1. Ito K et al. Runx3 expression in gastrointestinal tract epithelium: resolving the controversy. Oncogene 28, 1379-84 (2009) (PMID: 19169278) [WB] [IHC]
  2. Yano T et al. The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol. 26, 4474-88 (2006) (PMID: 16738314) [IHC]
Product category
Research area
Stem cell research
Cancer
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 00:05, Dec 14, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.