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HOME > Product search results > Code No. D234-3 Anti-RUNX3 mAb

Code No. D234-3

Anti-RUNX3 mAb

Availability (in Japan)

10 or more

(In Japan at 00:05,
Aug 18, 2018 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

    Data were kindly provided from Dr. Yoshiaki Ito and Dr. Kosei Ito. (Institute of Molecular and Cell Biology, Singapore)

  • Immunohistochemistry

    Data were kindly provided from Dr. Yoshiaki Ito and Dr. Kosei Ito. (Institute of Molecular and Cell Biology, Singapore)

Clonality Monoclonal Clone R3-6E9
Isotype (Immunized Animal) Mouse IgG1
Applications
WB
0.2-1 µg/mL  
IH
2 µg/mL (Heat treatment is necessary for paraffin embedded sections.)  
Immunogen (Antigen) Human RUNX3 polypeptide
Reactivity [Gene ID]

Human[864], Mouse[12399]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names RP3-398I9.1, AML2, CBFA3, PEBP2aC
Background The Runx (runt-related protein) family of transcription factors plays important roles in different tissues and cell lineages. Runx1 determines commitment to the hematopoietic cell lineage and Runx2 determines commitment to the osteoblastic lineage. Runx3 is involved in gastric epithelial growth and differentiation. PEBP2/Cbfβ is required for Runx-dependent transcriptional regulation. Runx proteins interact with many other transcription factors and co-regulators in the transcriptional regulation of their target genes.
Related products D235-3 Anti-RUNX3 mAb
D236-3 Anti-RUNX3 mAb
D207-3 Anti-Runx mAb
D208-3 Anti-Runx mAb
D130-3 Anti-Runx2 (Cbfa1) mAb
D127-3 Anti-PEBP2β (CBFβ) (Human) mAb
Citations

ChIP

  1. Chang TL et al Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells. Gastroenterology 138, 255-265 (2010)(PMID:19706291)
  2. Presnell SR et al. Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/15-treated conditions. J Immunol. 188, 4394-404 (2012)(PMID:22467658)
  3. Hor YT et al.A role for RUNX3 in inflammation-induced expression of IL23A in gastric epithelial cells. Cell Rep. 8, 50-8 (2014)(PMID:25008775)

Immunoprecipitation

  1. Qiao Y et al. RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer. Oncogene 35, 2664-74 (2016)(PMID:26364597)

Immunohistochemistry

  1. Chang TL et al Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells. Gastroenterology 138, 255-265 (2010)(PMID:19706291)
  2. Lin FC et al. RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. Oncogene 31, 4302-16 (2012)(PMID:22231444)
Product category
Research area
Stem cell research
Cancer
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  • The availability is based on the information in Japan at 00:05, Aug 18, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.