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HOME > Product search results > Code No. D070-3 Anti-CX3CR1 (Human) mAb

Code No. D070-3

Anti-CX3CR1 (Human) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Dec 17, 2017 in JST)

Size

100 µg/100 µL

Data
  • Flow Cytometry

Clonality Monoclonal Clone 2A9-1
Isotype (Immunized Animal) Rat IgG2bκ
Applications
FCM
5 µg/mL (final concentration)  
IF*
reported.  (PMID: 22916279
Function*
reported.  (PMID: 12743318 / 16278305 / 20512991
Immunogen (Antigen) Human CX3CR1 expressing non-mammalian cells
Reactivity [Gene ID]

Human[1524]

Storage buffer 1 mg/mL in PBS/50% glycerol/0.5M NaCl, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names chemokine (C-X3-C motif) receptor 1, CX3CR1
Background There are several subfamilies in the chemokine superfamily. In addition to CXC, CC and C subfamily, Fractalkine (FKN), which has the novel CX3C chemokine motif and the mucin-like domain, has recently been identified and reported. This mucin-chemokine hybrid type of protein can exist in two forms; either membrane-bound form or soluble secreted form. The membrane-bound form of FKN protein is markedly induced on primary endothelial cells by inflammatory cytokines, and it promotes strong adhesion of NK cells and CD8+ T cells. The soluble secreted form of FKN can be released, presumably by proteolysis at a membrane-proximal dibasic cleavage site, and has chemotactic activity for these leukocytes. CX3CR1, which is recently identified FKN receptor, is also G-protein-coupled seven-transmembrane receptor as another chemokine receptor family, and is expressed on the cell surface of NK cells and CD8+ T cells. It is also reported that CX3CR1 and FKN mediate both leukocytes migration and adhesion.
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D085-3 Anti-CD193 (CCR3) (Human) mAb
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D124-3 Anti-CD195 (CCR5) (Human) mAb
D124-4 Anti-CD195 (CCR5) (Human) mAb-FITC
D123-3 Anti-CD184 (CXCR4) mAb
D123-4 Anti-CD184 (CXCR4) mAb-FITC
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Citations

Flow Cytometry

  1. Harcourt J et al. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses. J Immunol. 76, 1600-8 (2006)(PMID:16424189)

Immunofluorescence

  1. Stolla M et al. Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1. PLoS One 7, e43572 (2012)(PMID:22916279)

Function

  1. Tripp RA et al. The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P. J Virol. 77, 6580-4 (2003)(PMID:12743318)
  2. Lee RH et al. A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice. Blood 107, 2153-61 (2006)(PMID:16278305)
  3. Aspinall AI et al. CX(3)CR1 and vascular adhesion protein-1-dependent recruitment of CD16(+) monocytes across human liver sinusoidal endothelium. Hepatology 51, 2030-9 (2010)(PMID:20512991)
  4. Johnson SM et al. Respiratory Syncytial Virus Uses CX3CR1 as a Receptor on Primary Human Airway Epithelial Cultures. PLoS Pathog. 11, e1005318 (2015)(PMID:26658574)
Product category
Research area
Cell surface antigens
Cytokine & Growth Factors
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  • The availability is based on the information in Japan at 01:30, Dec 17, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.