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エピジェネティクス


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ヒストンアセチル化測定キット

CycLex® Cellular Histone Acetylation Assay Kit
  1. Kaoru Nagai. Phytanic acid induces Neuro2a cell death via histone deacetylase activation and mitochondrial dysfunction. Neurotoxicol Teratol. 48, 33-9 (2015) （PMID：25619426）
  1. Ishiai S et al. Histone deacetylase inhibitory effect of Brazilian propolis and its association with the antitumor effect in Neuro2a cells. Food Sci Nutr. 2, 565-70 (2014) （PMID：25473514）
  1. Venturelli S et al. Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone proteins in human-derived hepatoblastoma cells. PLoS One. 8, e73097 (2013)（PMID：24023672）

ヒストン脱アセチル化酵素（HDAC・SIRT)測定キット

CycLex® SIRT3 Deacetylase Fluorometric Assay Kit Ver.2
  1. Ouyang J et al. SIRT3 Inactivation Promotes Acute Kidney Injury Through Elevated Acetylation of SOD2 and p53. J Surg Res. 233, 221-230 (2019)（PMID：30502252）
  1. Komatsu M et al. NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism. Sci Rep. 8, 8637 (2018)（PMID：29872122）
  1. Sun Y et al. Exogenous H2S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice. J Mol Med. 96, 281-299 (2018)（PMID：29349500）

※Cyclex® SIRT3 Deacetylase Fluoromeric Assay Kit (Code No. CY-1153)の後継品です。
  1. Wang Q et al. SIRT3 protects cells from hypoxia via PGC-1α- and MnSOD-dependent pathways. 286, 109-21 (2015)（PMID：25433241）
  1. Shulga N and Pastorino JG. Hexokinase II binding to mitochondria is necessary for Kupffer cell activation and is potentiated by ethanol exposure. J Biol Chem. 289, 26213-25 (2014)（PMID：25096575）
  1. Zhuge CC et al. Fullerenol protects retinal pigment epithelial cells from oxidative stress-induced premature senescence via activating SIRT1. Invest Ophthalmol Vis Sci. 55, 4628-38 (2014)（PMID：24845634）

CycLex® SIRT1/Sir2 Deacetylase Fluorometric Assay Kit Ver.2
  1. Chiang S et al. The potential of the novel NAD+ supplementing agent, SNH6, as a therapeutic strategy for the treatment of Friedreich's ataxia. Pharmacol Res.155, 104680 (2020)（PMID：32032665）
  1. Corbi G et al. Cardiac Rehabilitation Increases SIRT1 Activity and β-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction. Oxid Med Cell Longev. 2019, 7049237 (2019) （PMID：31885811）
  1. Yaku K et al. Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD).Sci Rep. 9, 13102 (2019)（PMID：31511627）

※CycLex® SIRT1/Sir2 Deacetylase Fluorometric Assay Kit（Code No. CY-1151）の後継品です。
  1. Pang J et al. Effect of NAD on PARP-mediated insulin sensitivity in oleic acid treated hepatocytes. J Cell Physiol. 230, 1607-13 (2015)（PMID：25536389）
  1. Li D et al. A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer. Sci Rep. 4, 6666 (2014)（PMID：25323003）
  1. Hsu CY and Hu TH. Energy-regulated molecules maintain young status in the trophocytes and fat cells of old queen honeybees. Biogerontology. 15, 389-400 (2014)（PMID：24973265）

CycLex® HDACs Deacetylase Fluorometric Assay Kit Ver.2
  1. Kaoru Nagai. Phytanic acid induces Neuro2a cell death via histone deacetylase activation and mitochondrial dysfunction. Neurotoxicol Teratol. 48, 33-9 (2015) （PMID：25619426）
  1. Ishiai S et al. Histone deacetylase inhibitory effect of Brazilian propolis and its association with the antitumor effect in Neuro2a cells. Food Sci Nutr. 2, 565-70 (2014) （PMID：25473514）
  1. Suzuki T et al. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS One. 8, e68669 (2013)（PMID：23874714）

※CycLex® HDACs Deacetylase Fluorometric Assay Kit（Code No. CY-1150）の後継品です。
  1. Ishiai S et al. Histone deacetylase inhibitory effect of Brazilian propolis and its association with the antitumor effect in Neuro2a cells. Food Sci Nutr. 2, 565-70 (2014)（PMID：25473514）
  1. Suzuki T et al. Design, Synthesis, and Biological Activity of NCC149 Derivatives as Histone Deacetylase 8 Selective Inhibitors ChemMedChem. 9, 657-64 (2014)（PMID：24403121）
  1. Suzuki T et al. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS One. 8, e68669 (2013)（PMID：23874714）



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