Code No. | Product name | Synonyms | Reactivity | Applications | Function, localization |
---|---|---|---|---|---|
RN063PW | Anti-DHX9 pAb | NDHII, RHA | Hu/ Mo/ Ham | WB/ IP | DHX9 is an RNA helicase that shuttles between nucleus and cytoplasm. DHX9 is a RISC component involved in siRNA/miRNA loading onto RISC. |
RN030PW | Anti-DICER1 (Human) pAb | DCR1, Dicer | Hu | WB/ IP | DICER1, an endonuclease of the RNase III familiy, cleaves dsRNAs or pre-miRNA to yield siRNA or miRNA duplex. It also plays a role in loading small RNA duplex onto RISC. |
RN003M | Anti-EIF2C2 (AGO2) (Human) mAb | AGO2 | Hu | WB/ IP/ RIP | AGO2, a core component of RNA-induced silencing complex (RISC), plays a central role in RNAi pathway. It is reported that AGO2 is localized to P-body and involved in mRNA decay. |
RN016P | Anti-FMR1 pAb | FMRP | Hu/ Mo/ Rat | WB/ IP/ RIP | FMR1 contributes to binding of Dicer-processed miRNA to mRNA through interaction with Dicer and RISC. |
RN125PW | Anti-HENMT1 pAb | HEN1, C1orf59 | Hu/ Mo/ Rat | WB | HENMT1, small RNA 2'-O-methyltransferase, mediates stabilization of piRNA by adding 2'-O-methyl group to the 3'-end of mammalian piRNAs. HENMT1 is preferentially expressed in testis and required for mouse spermatogenesis. |
RN114PW | Anti-HNRNPA1 pAb | Hu/ Mo/ Rat/ Ham(w) | WB/ IP | HNRNPA1 is a multi-functional DNA/RNA binding protein involved in transcription, pre-mRNA splicing, stability, translation and miRNA biogenesis. HNRNPA1 participates in processing by Drosha via binding to pri-miR-18 and pri-let-7a. | |
RN127PW | Anti-NSUN2 (Human) pAb | MISU, MRT5, SAKI, TRM4 | Hu | WB/ IP | NSUN2, identified as tRNA m5C methyltransferase, catalyzes the conversion of cytidine to m5C in tRNAs, mRNA and miRNA. m5C RNA modifications by NSUN2 affects mRNA stability, translation regulation and miRNA biogenesis. |
RN009M | Anti-PABPC1 mAb | PABP1 | Hu/ Ham | WB/ IP/ RIP/ IC | PABPC1 promotes miRNA-mediated translational repression and/or decay of its target mRNA via binding to GW182. |
RN058PW | Anti-TARBP2 pAb | TRBP | Hu/ Rat | WB | TARBP2, one of the RISC components, serves as a binding partner of Dicer. It binds to guide strand of miRNA duplex after dicing. It is reported that TARBP2 is involved in transfer of siRNA and miRNA from Dicer to AGO2. |
RN107PW | Anti-TARDBP (TDP-43) pAb | TDP-43 | Hu/ Mo/ Ham | WB/ IP | TARDBP (TDP-43) is a nuclear DNA/RNA binding protein involved in mRNA splicing, nuclear export, stability, miRNA biogenesis and transcriptional repression. TARDBP promotes miRNA processing in both nucleus and cytoplasm as a component of Drosha and Dicer complexes. |
RN033P | Anti-TNRC6A (GW182) pAb | GW182, GW1 | Hu/ Mo/ Rat | WB/ IP/ RIP/ IC* | TNRC6A/GW182, associated with gene silencing by small ncRNA such as miRNA, has RNA recognition motif and several AGO binding domains. It serves as a trasnlational repressor of mRNA via binding to RISC components. It is reported that TNRC6A/GW182 is a major component of P-body/GW-body. |
For applications and reactivities:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: Information from the licensor (Not tested by MBL). Please check the data sheet for detailed information.