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Nuclear export


Code No. Product name Synonyms Reactivity Applications Function, localization
RN122PW Anti-ALKBH5 pAb 　 Hu/ Mo WB/ IP ALKBH5 is one of mammalian m6A demethylase, localized in nuclear speckles, catalyzes the direct removal of m6A modification on nuclear RNA and its demethylation affects RNA processing and RNA export.
RN001P Anti-EIF4E pAb 　 Hu/ Mo/ Rat/ Ham WB/ IP/ RIP/ IC/ IF EIF4E, one of the translation-intiation factor, binds to m7G cap structure. It is also related to export of mRNA from nucleus to cytoplasm.
RN006M Anti-EIF4E mAb 　 Hu/ Mo/ Rat/ Ham WB/ IP/ RIP EIF4E, one of the translation-intiation factor, binds to m7G cap structure. It is also related to export of mRNA from nucleus to cytoplasm.
RN004P Anti-ELAVL1 (HuR) pAb HuR Hu/ Mo/ Rat/ Ham WB/ IP/ RIP/ IC/ IF ELAVL1/HuR, a ubiquitously expressed protein, binds to both poly(A) and AU-rich element of mRNA. It is reported that HuR regulates mRNA export via shuttling between nucleus and cytoplasm.
RN007M Anti-ELAVL1 (HuR) mAb HuR Hu/ Mo/ Rat/ Ham WB/ IP/ RIP ELAVL1/HuR, a ubiquitously expressed protein, binds to both poly(A) and AU-rich element of mRNA. It is reported that HuR regulates mRNA export via shuttling between nucleus and cytoplasm.
RN016P Anti-FMR1 pAb FMRP Hu/ Mo/ Rat WB/ IP/ RIP FMR1 is necessary for neurogenesis and strongly binds to poly(G) sequenses. The expanded CGG repeats within the FMR1 genes is found in Fragile X syndrome patients.
RN048PW Anti-G3BP1 pAb G3BP Hu WB/ IP G3BP1, a DNA/RNA helicase, is related to a stress granule formation. It is also involved in mRNA export via interaction with nuclear pore complex.
RN114PW Anti-HNRNPA1 pAb 　 Hu/ Mo/ Rat/ Ham(w) WB/ IP HNRNPA1 is a multi-functional DNA/RNA binding protein involved in transcription, pre-mRNA splicing, stability, translation and miRNA biogenesis. HNRNPA1 shuttles between nucleus and cytoplasm and is also involved in nuclear export.
RN052PW Anti-HNRNPC pAb 　 Hu/ Mo WB/ IP HNRNPC is related to nuclear exprot of mRNAs via binding to both cap binding complex and neighborhood of cap structure of mRNA, of which the length is more than 200 nt.
RN019P Anti-HNRNPK pAb HNRPK Hu/ Mo/ Rat WB/ IP/ RIP/ IC* HNRNPK, one of the components of hnRNP complex, shuttles between nucleus and cytoplasm. It is related to splicing, transport and translational regulation of mRNA.
RN001M Anti-IGF2BP1 (IMP1) mAb IMP1, ZBP1 Hu/ Mo WB/ IP/ RIP Together with FMRP, IGF2BP1 binds to β-actin mRNA and trasnports it from nucleus to cytoplasm.
RN007P Anti-IGF2BP1 (IMP1) pAb IMP1, ZBP1 Hu/ Mo WB/ IP/ RIP/ IC/ IF Together with FMRP, IGF2BP1 binds to β-actin mRNA and trasnports it from nucleus to cytoplasm.
RN008P Anti-IGF2BP2 (IMP2) pAb IMP2 Hu/ Mo/ Rat WB/ IP/ RIP/ IC/ IF IGF2BP2 binds to the UTR of IGF2 leader 3 mRNA, which is related to development and proliferation, and regulates its translation.
RN009P Anti-IGF2BP3 (IMP3) pAb IMP3 Hu/ Mo WB/ IP/ RIP IGF2BP3 binds to the 5'-UTR of IGF2 leader 3 mRNA, which is related to development and proliferation, and regulates its translation.
RN009M Anti-PABPC1 mAb PABP1 Hu/ Ham WB/ IP/ RIP/ IC PABPC1 shuttles between nucleus and cytoplasm. It has been reported that PABPC1 is translocated in nucleus in viral infection and may be involved in viral RNA or host mRNA processing and/or export.
RN080PW Anti-SRSF3 (SRp20) pAb SRp20 Hu/ Mo/ Rat/ Ham WB/ IP/ IC/ IF SRSF3/SRp20 shuttles between nucleus and cytoplasm. It is related to transport of histone mRNA by binding to TAP together with SRSF7.
RN082PW Anti-SRSF5 (SRP40) pAb SRP40 Hu/ Mo/ Rat/ Ham WB/ IP SRSF5/SRp40 is involved in transport of non-spliced gag-pol mRNA and partially spliced env mRNA of HIV-1.
RN079PW Anti-SRSF7 (9G8) pAb 9G8 Hu/ Mo/ Ham WB/ IP SRSF7/9G8 shuttles between nucleus and cytoplasm. It is related to transport of histone mRNA through interaction with TAP/NXF1.
RN012P Anti-STAU1 (Human) pAb 　 Hu WB/ IP/ RIP STAU1 forms RNA granules in neuronal cells. It is reported that STAU1 regulates export and localization of mRNA via binding to dsRNAs and microtubles.
RN013P Anti-STAU2 (Human) pAb 　 Hu WB/ IP/ RIP STAU2 is highly homologous to STAU1, but their function may be different because they do not co-localize in neuronal cells. It shuttles between nucleus and cytoplasm, however, the function in detail is unknown.
RN107PW Anti-TARDBP (TDP-43) pAb TDP-43 Hu/ Mo/ Ham WB/ IP TARDBP (TDP-43) is a nuclear DNA/RNA binding protein involved in mRNA splicing, nuclear export, stability, miRNA biogenesis and transcriptional repression. TARDBP is mainly localized in nucleus, however, it shuttles between nucleus and cytoplasm.




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