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HOME > Product category > RNA-RNP Network > Splicing

Splicing


Code No. Product name Synonyms Reactivity Applications Function, localization
RN122PW Anti-ALKBH5 pAb 　 Hu/ Mo WB/ IP ALKBH5 is one of mammalian m6A demethylase, localized in nuclear speckles, catalyzes the direct removal of m6A modification on nuclear RNA and its demethylation affects RNA processing and RNA export.
RN035PW Anti-CUGBP2 mAb CELF2 Hu/ Mo/ Rat/ Ham WB CUGBP2 is highly expressed in most tissues including muscle. It induces apoptosis in tumor cells via binding to 3'-UTR of Mcl-1 mRNA.
RN064PW Anti-FUSIP1 (SRSF10) pAb FUSIP1, TASR Hu/ Mo/ Ham WB/ IP FUSIP1/SRSE10 is activated by dephosphorylation in response to meiosis or heat shock, and negatively regulates pre-mRNA splicing.
RN114PW Anti-HNRNPA1 pAb 　 Hu/ Mo/ Rat/ Ham(w) WB/ IP HNRNPA1 is a DNA/RNA binding protein involved in transcription, pre-mRNA splicing, stability, translation and miRNA biogenesis. HNRNPA1 regulates alternative splicing by binding to pre-mRNA in competition with SR proteins.
RN052PW Anti-HNRNPC pAb 　 Hu/ Mo WB/ IP HNRNPC is involved in alternative splicing through forming a tetrameric complex followed by binding to splice site of pre-mRNA.
RN019P Anti-HNRNPK pAb HNRPK Hu/ Mo/ Rat WB/ IP/ RIP/ IC* HNRNPK, one of the components of hnRNP complex, shuttles between nucleus and cytoplasm. It is related to splicing, transport and translational regulation of mRNA.
RN013MW Anti-Nono (P54NRB) mAb p55nrb Mo/ Rat/ Ham WB/ IP/ IC/ IH p54nrb/Nono binds both DNA and RNA. It is involved in transcriptional regulation, splicing and nuclear retention of A-to-I edited RNA. It binds to ncRNA NEAT2 (MENε/β） and particitates in structural maintenance of paraspeckle.
RN092PW Anti-NONO (P54NRB) pAb p54nrb Hu/ Mo/ Rat/ Ham WB/ IP p54nrb/NONO binds both DNA and RNA. It is involved in transcriptional regulation, splicing and nuclear retention of A-to-I edited RNA. It binds to ncRNA NEAT1 (MENε/β） and particitates in structural maintenance of paraspeckle.
RN011P Anti-PTBP1 (Human) pAb hnRNP I Hu WB/ IP/ RIP/ IF* PTBP1 is related to alternative splicing and negatively regulates the splice sites via binding to intronic cluster of pre-mRNA.
RN014MW Anti-SFPQ (PSF) mAb PSF Hu/ Mo/ Rat/ Ham WB/ IP/ IC/ IH SFPQ (PSF) is one of core paraspeckle proteins involved in the structural maintenance of the paraspeckle by binding to p54nrb and ncRNA NEAT1. SFPQ functions as a repressor of exon skipping of CD45 and iclusion of tau exon 10.
RN077PW Anti-SMN1 pAb 　 Hu WB/ IP SMN1 gene is a responsible for spinal muscular atrophy (SMA). SMN1 is related to snRNP assembly via binding to U snRNA and post-trascriptional modification of U snRNA in Cajal body.
RN095PW Anti-SNRNP200 pAb ASCC3L1, RP33 Hu/ Mo/ Ham WB/ IP SNRNP200, one of the components of U4/U5-U6 spliceosome, is required for unwinding of U4/U6 snRNAs in activation of spliceosome. It is also known that mutation of SNRNP200 gene causes autosomal-dominant retinitis pigmentosa.
RN080PW Anti-SRSF3 (SRp20) pAb SRp20 Hu/ Mo/ Rat/ Ham WB/ IP/ ICC/ IF SRSF3/SRp20 plays a role in alternative splicing of exon 11 of insulin receptor via interaction with CUGBP1.
RN082PW Anti-SRSF5 (SRP40) pAb SRP40 Hu/ Mo/ Rat/ Ham WB/ IP SRSF5/SRp40 promotes splicing of the upstream of 3' splice site and binding U1 snRNP to 5' splice site via interacts with purin-rich region in HIV-1 exon 5.
RN079PW Anti-SRSF7 (9G8) pAb 9G8 Hu/ Mo/ Ham WB/ IP SRSF7/9G8 repress the exon inclusion via binding to the intronic silencer located downstream of Tau exon 10.
RN081PW Anti-SRSF9 (SRp30c) pAb SRp30c Hu/ Mo/ Rat/ Ham WB/ IP SRSF9/SRp30c functions as a splicing repressor in alternative splicing of hnRNP A1, Bcl-x and Tau mRNAs.
RN107PW Anti-TARDBP (TDP-43) pAb TDP-43 Hu/ Mo/ Ham WB/ IP TARDBP (TDP-43) is a nuclear DNA/RNA binding protein involved in mRNA splicing, nuclear export, stability, miRNA biogenesis and transcriptional repression. TARDBP promotes alternative splicing of CFTR, apoA-II and H-ras pre-mRNA.
RN014P Anti-TIA1 (Human) pAb 　 Hu/ Mo/ Rat/ Ham WB/ IP/ RIP TIA1 shuttles between nucleus and cytoplasm. It is related to alternative splicing of Fas and FGFR2 mRNAs.
RN059PW Anti-TIAL1 pAb TIAR Hu/ Rat/ Ham WB/ IP TIAL1 regulates splicing via binding to U-rich region of mRNA. It also represses skipping of exon 7 in SMN2 gene by binding to the intron.
RN085PW Anti-U2AF1 pAb U2AF35 Hu/ Mo/ Rat/ Ham WB/ IP/ IC/ IF U2AF1, a splicing regulator, binds to AG-dinucleotides of 3' splice site of pre-mRNA. It is involved in recruit of tri-snRNP and formation of stable spliceosome through interaction with SMDC1.
RN015P Anti-YBX1 pAb 　 Hu/ Mo/ Rat/ Ham WB/ IP/ RIP/ ChIP* YBX1, a member of cold shock protein family, is one of the main components of cytoplasmic mRNP particles. Some reports indicate that it is related to splicing of mRNA.


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