Code No. |
Product name |
Synonyms |
Reactivity |
Applications |
Function, localization |
RN122PW
|
Anti-ALKBH5 pAb
|
|
Hu/ Mo |
WB/ IP |
ALKBH5 is one of mammalian m6A demethylase, localized in nuclear speckles, catalyzes the direct removal of m6A modification on nuclear RNA and its demethylation affects RNA processing and RNA export.
|
RN035PW |
Anti-CUGBP2 mAb |
CELF2 |
Hu/ Mo/ Rat/ Ham |
WB |
CUGBP2 is highly expressed in most tissues including muscle. It induces apoptosis in tumor cells via binding to 3'-UTR of Mcl-1 mRNA. |
RN064PW |
Anti-FUSIP1 (SRSF10) pAb |
FUSIP1, TASR |
Hu/ Mo/ Ham |
WB/ IP |
FUSIP1/SRSE10 is activated by dephosphorylation in response to meiosis or heat shock, and negatively regulates pre-mRNA splicing. |
RN114PW |
Anti-HNRNPA1 pAb |
|
Hu/ Mo/ Rat/ Ham(w) |
WB/ IP |
HNRNPA1 is a DNA/RNA binding protein involved in transcription, pre-mRNA splicing, stability, translation and miRNA biogenesis. HNRNPA1 regulates alternative splicing by binding to pre-mRNA in competition with SR proteins. |
RN052PW |
Anti-HNRNPC pAb |
|
Hu/ Mo |
WB/ IP |
HNRNPC is involved in alternative splicing through forming a tetrameric complex followed by binding to splice site of pre-mRNA. |
RN019P |
Anti-HNRNPK pAb |
HNRPK |
Hu/ Mo/ Rat |
WB/ IP/ RIP/ IC* |
HNRNPK, one of the components of hnRNP complex, shuttles between nucleus and cytoplasm. It is related to splicing, transport and translational regulation of mRNA. |
RN013MW |
Anti-Nono (P54NRB) mAb |
p55nrb |
Mo/ Rat/ Ham |
WB/ IP/ IC/ IH |
p54nrb/Nono binds both DNA and RNA. It is involved in transcriptional regulation, splicing and nuclear retention of A-to-I edited RNA. It binds to ncRNA NEAT2 (MENε/β) and particitates in structural maintenance of paraspeckle. |
RN092PW |
Anti-NONO (P54NRB) pAb |
p54nrb |
Hu/ Mo/ Rat/ Ham |
WB/ IP |
p54nrb/NONO binds both DNA and RNA. It is involved in transcriptional regulation, splicing and nuclear retention of A-to-I edited RNA. It binds to ncRNA NEAT1 (MENε/β) and particitates in structural maintenance of paraspeckle. |
RN011P |
Anti-PTBP1 (Human) pAb |
hnRNP I |
Hu |
WB/ IP/ RIP/ IF* |
PTBP1 is related to alternative splicing and negatively regulates the splice sites via binding to intronic cluster of pre-mRNA. |
RN014MW |
Anti-SFPQ (PSF) mAb |
PSF |
Hu/ Mo/ Rat/ Ham |
WB/ IP/ IC/ IH |
SFPQ (PSF) is one of core paraspeckle proteins involved in the structural maintenance of the paraspeckle by binding to p54nrb and ncRNA NEAT1. SFPQ functions as a repressor of exon skipping of CD45 and iclusion of tau exon 10. |
RN077PW |
Anti-SMN1 pAb |
|
Hu |
WB/ IP |
SMN1 gene is a responsible for spinal muscular atrophy (SMA). SMN1 is related to snRNP assembly via binding to U snRNA and post-trascriptional modification of U snRNA in Cajal body. |
RN095PW |
Anti-SNRNP200 pAb |
ASCC3L1, RP33 |
Hu/ Mo/ Ham |
WB/ IP |
SNRNP200, one of the components of U4/U5-U6 spliceosome, is required for unwinding of U4/U6 snRNAs in activation of spliceosome. It is also known that mutation of SNRNP200 gene causes autosomal-dominant retinitis pigmentosa. |
RN080PW |
Anti-SRSF3 (SRp20) pAb |
SRp20 |
Hu/ Mo/ Rat/ Ham |
WB/ IP/ ICC/ IF |
SRSF3/SRp20 plays a role in alternative splicing of exon 11 of insulin receptor via interaction with CUGBP1. |
RN082PW |
Anti-SRSF5 (SRP40) pAb |
SRP40 |
Hu/ Mo/ Rat/ Ham |
WB/ IP |
SRSF5/SRp40 promotes splicing of the upstream of 3' splice site and binding U1 snRNP to 5' splice site via interacts with purin-rich region in HIV-1 exon 5. |
RN079PW |
Anti-SRSF7 (9G8) pAb |
9G8 |
Hu/ Mo/ Ham |
WB/ IP |
SRSF7/9G8 repress the exon inclusion via binding to the intronic silencer located downstream of Tau exon 10. |
RN081PW |
Anti-SRSF9 (SRp30c) pAb |
SRp30c |
Hu/ Mo/ Rat/ Ham |
WB/ IP |
SRSF9/SRp30c functions as a splicing repressor in alternative splicing of hnRNP A1, Bcl-x and Tau mRNAs. |
RN107PW |
Anti-TARDBP (TDP-43) pAb |
TDP-43 |
Hu/ Mo/ Ham |
WB/ IP |
TARDBP (TDP-43) is a nuclear DNA/RNA binding protein involved in mRNA splicing, nuclear export, stability, miRNA biogenesis and transcriptional repression. TARDBP promotes alternative splicing of CFTR, apoA-II and H-ras pre-mRNA. |
RN014P |
Anti-TIA1 (Human) pAb |
|
Hu/ Mo/ Rat/ Ham |
WB/ IP/ RIP |
TIA1 shuttles between nucleus and cytoplasm. It is related to alternative splicing of Fas and FGFR2 mRNAs. |
RN059PW |
Anti-TIAL1 pAb |
TIAR |
Hu/ Rat/ Ham |
WB/ IP |
TIAL1 regulates splicing via binding to U-rich region of mRNA. It also represses skipping of exon 7 in SMN2 gene by binding to the intron. |
RN085PW |
Anti-U2AF1 pAb |
U2AF35 |
Hu/ Mo/ Rat/ Ham |
WB/ IP/ IC/ IF |
U2AF1, a splicing regulator, binds to AG-dinucleotides of 3' splice site of pre-mRNA. It is involved in recruit of tri-snRNP and formation of stable spliceosome through interaction with SMDC1. |
RN015P |
Anti-YBX1 pAb |
|
Hu/ Mo/ Rat/ Ham |
WB/ IP/ RIP/ ChIP* |
YBX1, a member of cold shock protein family, is one of the main components of cytoplasmic mRNP particles. Some reports indicate that it is related to splicing of mRNA. |