The tyrosine kinases are divided into two main families: the receptor tyrosine kinase (RTK) and cytoplasmic protein (Non-receptor tyrosine kinase). Receptor tyrosine kinases (RTK)s are the high-affinity cell surface receptors for many growth factors, cytokines, and hormones. Both families play critical roles in a variety of cellular signal transduction pathways, regulating such diverse processes as cell division, adhesion, angiogenesis, and survival. These also have a main role in the development and progression of many types of cancer.
CycLex c-Src Kinase Assay/Inhibitor Screening Kit is designed to measure the activities of recombinant catalytic domain of c-Src for the rapid and sensitive evaluation of inhibitors or activators.
The Src family of non-receptor protein tyrosine kinases plays critical roles in a variety of cellular signal transduction pathways, regulating such diverse processes as cell division, motility, adhesion, angiogenesis, and survival. Constitutively activated variants of Src family kinases, including the viral oncoproteins v-Src and v-Yes, are capable of inducing malignant transformation of a variety of cell types. Src family kinases, most notably although not exclusively Src, are frequently overexpressed and/or aberrantly activated in a variety of epithelial and non-epithelial cancers.