Tyrosine Kinase Assay Kits

The tyrosine kinases are divided into two main families: the receptor tyrosine kinase (RTK) and cytoplasmic protein (Non-receptor tyrosine kinase). Receptor tyrosine kinases (RTK)s are the high-affinity cell surface receptors for many growth factors, cytokines, and hormones. Both families play critical roles in a variety of cellular signal transduction pathways, regulating such diverse processes as cell division, adhesion, angiogenesis, and survival. These also have a main role in the development and progression of many types of cancer.

CycLex Met Kinase Assay/Inhibitor Screening Kit is designed to measure the activities of recombinant catalytic domain of Met for the rapid and sensitive evaluation of inhibitors or activators.
Met is involved in malignant cell transformation. Increased Met expression has been found in a significant percentage of human cancers and is amplified during the transition between primary tumors and metastasis. Dysregulation of Met activity in cells is thought to be a key event underlying tumor metastasis, and indeed, Met overexpression and hyperactivation are reported to correlate with metastatic ability of the tumor cells.

Met Kinase Assay/Inhibitor Screening Kit　

CycLex c-Src Kinase Assay/Inhibitor Screening Kit is designed to measure the activities of recombinant catalytic domain of c-Src for the rapid and sensitive evaluation of inhibitors or activators.
The Src family of non-receptor protein tyrosine kinases plays critical roles in a variety of cellular signal transduction pathways, regulating such diverse processes as cell division, motility, adhesion, angiogenesis, and survival. Constitutively activated variants of Src family kinases, including the viral oncoproteins v-Src and v-Yes, are capable of inducing malignant transformation of a variety of cell types. Src family kinases, most notably although not exclusively Src, are frequently overexpressed and/or aberrantly activated in a variety of epithelial and non-epithelial cancers.

c-Src Kinase Assay/Inhibitor Screening Kit