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“Anti-p62 antibodyアイコン"

Anti-p62 antibody

p62/SQSTM1 is a scaffolding protein that interacts with various signaling molecules such as TRAF6, RIP, and aPKC. p62 contains an LC3-interacting region and is believed to be a substrate for selective autophagy. In addition, p62 contains a domain that binds ubiquitin chains, and mediates the recruitment of poly ubiquitinated protein aggregates and depolarized mitochondria to the autophagic machinery. In fact, in liver- and brain-specific autophagy-deficient mice, overaccumulation of p62 occurs, and ubiquitin- and p62-positive inclusion bodies are observed. Importantly, ubiquitin- and p62-positive inclusion bodies are also observed in tissues of patients with neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis), alcoholic hepatitis, hepatic steatosis, and liver cancer. There is increasing interest in the involvement of impaired autophagic degradation of p62 in these diseases.

■ p62/SQSTM1 domain structure
p62/SQSTM1のドメイン構造Anti-p62 (SQSTM1) pAbのImmunohistochemistry

See product data; Anti-p62 (SQSTM1) pAb(Code No. PM045)→

Anti-p62 antibodies

* : Literature review
Code No. Clone Isotype Immunogen Reactivity Application Conjugate
M162-3 5F2 Mouse Hu p62
Hu ★★★ ★★★ ★★★ ★★★ ★★
M162-A48 5F2 Mouse Hu p62
★★★★ ★★★ Alexa Fluor® 488
M162-A59 5F2 Mouse Hu p62
★★★ Alexa Fluor® 594
M162-A64 5F2 Mouse Hu p62

★★★ Alexa Fluor® 647
PM045 Polyclonal Rabbit Hu p62
Hu, Mo, Rat, Hm ★★★ ★★★ ★★★ ★★★ ★*
Polyclonal Guinea Pig Hu p62
Hu, Mo, Rat, Hm ★★★★ ★★★ ★★★ ★★★

Product data; Anti-p62 antibodies

Anti-p62 (SQSTM1) (Human) mAbのImmunohistochemistory, Immunoprecipitation

■ Western blotting
Anti-p62 (SQSTM1) pAbのWestern blotting

Anti-p62 C-terminal pAbの製品データ