Anti-p62 antibody

p62/SQSTM1 is a scaffolding protein that interacts with various signaling molecules such as TRAF6, RIP, and aPKC. p62 contains an LC3-interacting region and is believed to be a substrate for selective autophagy. In addition, p62 contains a domain that binds ubiquitin chains, and mediates the recruitment of poly ubiquitinated protein aggregates and depolarized mitochondria to the autophagic machinery. In fact, in liver- and brain-specific autophagy-deficient mice, overaccumulation of p62 occurs, and ubiquitin- and p62-positive inclusion bodies are observed. Importantly, ubiquitin- and p62-positive inclusion bodies are also observed in tissues of patients with neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis), alcoholic hepatitis, hepatic steatosis, and liver cancer. There is increasing interest in the involvement of impaired autophagic degradation of p62 in these diseases.

■ p62/SQSTM1 domain structure

See product data; Anti-p62 (SQSTM1) pAb（Code No. PM045）→

* : Literature review

Code No.	Clone	Isotype	Immunogen	Reactivity	Application						Conjugate
					WB	IP	IC	IH	FCM	Immuno-EM
M162-3	5F2	Mouse	Hu p62 (120-440aa)	Hu	★★★	★★★	★★★	★★★	★★
M162-A48	5F2	Mouse	Hu p62 (120-440aa)	Hu			★★★★		★★★		Alexa Fluor® 488
M162-A59	5F2	Mouse	Hu p62 (120-440aa)	Hu			★★★				Alexa Fluor® 594
M162-A64	5F2	Mouse	Hu p62 (120-440aa)	Hu			★★★		★★★		Alexa Fluor® 647
PM045	Polyclonal	Rabbit	Hu p62 (120-440aa)	Hu, Mo, Rat, Hm	★★★	★★★	★★★	★★★		★*
PM066	Polyclonal	Guinea Pig	Hu p62 (C-terminal)	Hu, Mo, Rat, Hm	★★★★	★★★	★★★	★★★

■ Western blotting