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Atg12-Atg5 complex and Atg16L

Unlike other ubiquitin-like proteins, the ubiquitin-like protein Atg12 has a C-terminal glycine, which protects it from processing. Atg12 is conjugated to the substrate Atg5 by Atg7 (an E1-like protein, and as seen in the conjugation of Atg8 to PE) and Atg10 (an E2-like protein). The Atg12-Atg5 conjugate forms a complex with Atg16. Self-oligomerization of Atg16 results in a multimer of the Atg12-Atg5-Atg16 complex.
Although its functions remain unknown, this complex is shown to accumulate on the pre-autophagosomal structure (PAS) in yeast and to play an essential role in autophagosome formation.

Product data; Anti-Atg5 antibodies

■ Western blotting
Anti-Atg5 pAb(Code No. PM050)Western blotting

■ Western blotting
Anti-Atg5 mAb(Code No. M153-3, Clone:4D3) Western Blotting

Product data; Anti-Atg12 antibody

■ Immunoprecipitation
Anti-Atg12 (Human) mAb(Code No. M154-3)Immunoprecipitation

Product data; Anti-Atg10 antibody

■ Western blotting
Anti-Atg10 (Human) mAb(Code No. M151-3)Western blotting

Product data; Anti-Atg16 antibodies

■ Western blotting
Anti-Atg16L mAb(Code No. M150-3, Clone:1F12)のWestern blotting

■ Immunoprecipitation
Anti-Atg16L pAb(Code No. PM040)のImmunoprecipitation