Kit, protein, vector, etc detailed product information

Code No. 4800-520 プリントPrint out
Caspase inhibitor Z-VAD-FMK
Price ¥40,000
Size 20 µL
Availability (in Japan) 10 or more
(In Japan at 00:05, Aug 14, 2020 in JST)
Storage temp. -20°C
Manufacturer MBL
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4815 APOPCYTO™ Caspase-3 Fluorometric Assay Kit
4805 APOPCYTO™ Caspase-8 Colorimetric Assay Kit
4820 APOPCYTO™ Caspase-8 Fluorometric Assay Kit
4810 APOPCYTO™ Caspase-9 Colorimetric Assay Kit
4825 APOPCYTO™ Caspase-9 Fluorometric Assay Kit
Product category Research area:Apoptosis
Citations
  1. Ito T et al. Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C. Carcinogenesis. 24, 1489-97 (2003)(PMID:12844481)
  1. Kobayashi S et al. 53BP2 induces apoptosis through the mitochondrial death pathway. Genes Cells. 10, 253-60 (2005)(PMID:15743414)
  1. Matsumoto T et al. Antiproliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells. Planta Med. 72, 276-8 (2006)(PMID:16534737)
  1. Nakagawa Y et al. Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. Bioorg Med Chem. 15, 5620-8 (2007)(PMID:17553685)
  1. Yuan G et al. The distribution and ultrastructure of the forming blood capillaries and the effect of apoptosis on vascularization in mouse embryonic molar mesenchyme. Cel Tissue Res. 356, 137-45 (2014)(PMID:24477797)
  1. Kozako T et al. Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells. Sci Rep. 5, 11345 (2015)(PMID:26091232)
  1. Sagiv A et al. Granule exocytosis mediates immune surveillance of senescent cells. Oncogene 32, 1971–1977 (2013)(PMID:26935269)
  1. Wang C et al. A bead-based cleavage method for large-scale identification of protease substrates. Sci Rep. 6, 22645 (2016)(PMID:26935269)
  1. Kitazawa M et al. ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction-Mediated Intercellular Communication. PLoS One. 12, e0169340 (2017)(PMID:28056049)
  1. Tokunaga E et al. Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others. PLoS One. 12, e0182152 (2017)(PMID:28763493)
  1. Hsu JM et al. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Nat Commun. 9, 1908 (2018)(PMID:29765039)
  1. Kozako T et al. The small molecule STF-62247 induces apoptotic and autophagic cell death in leukemic cells. Oncotarget 9, 27645-27655 (2018)(PMID:29963226)
  1. Kozako T et al. Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. BMC Cancer. 18, 791 (2018)(PMID:30081901)
  1. Hirasawa M, Kurita-Ochiai T. Porphyromonas gingivalis Induces Apoptosis and Autophagy via ER Stress in Human Umbilical Vein Endothelial Cells. Mediators Inflamm. 2018, 1967506 (2018)(PMID:30150893)
  1. Zhang E et al. The functional role of Bax/Bak in palmitate-induced lipoapoptosis. Food Chem Toxicol. 123, 268-274 (2019)(PMID:30408539)
  1. Sanjo H et al. Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death. J Immunol. 203, 783-788 (2019)(PMID:31243089)
  1. Matsuo K et al. Delta-like 3 localizes to neuroendocrine cells and plays a pivotal role in gastrointestinal neuroendocrine malignancy. Cancer Sci. 110, 3122-3131 (2019)(PMID:31369178)
  1. Sasaki K et al. Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death. Nat Commun. 10, 3878 (2019)(PMID:31462647)

Function

  1. Hoshi T et al. Lenvatinib induces death of human hepatocellular carcinoma cells harboring an activated FGF signaling pathway through inhibition of FGFR-MAPK cascades. Biochem Biophys Res Commun. 513, 1-7 (2019)(PMID:30944079)
  2. Aoki K et al. Coordinated changes in cell membrane and cytoplasm during maturation of apoptotic bleb. Mol Biol Cell. 31, 833-844 (2020)(PMID:32049595)
References
  1. Slee EA et al. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J. 315, 21-24 (1996)(PMID: 8670109
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