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HOME > Product search results > Code No. U-V002-01
Recombinant human VWF-A1 domain (residues 1261-1468 VWD type 2B)
Code No. U-V002-01
Recombinant human VWF-A1 domain (residues 1261-1468 VWD type 2B)
Price
¥104,000
Availability (in Japan)
0
(Contact us)
（In Japan at 00:05,
Feb 17, 2025 in JST）
Size
100 µg
Data SheetOnly available for the customers in Singapore, Taiwan and South Korea
Storage and Stability:VWF-A1 should be stored at -80℃ (stable for at least 1 year). The buffer contains 25 mM tris 350 mM NaCl pH 7.8 without preservative. After thawing it should be stored in appropriate small aliquots at -20℃ or -80℃ (stable for at least 2 months). For maximal stability the concentration NaCl should be at least 100 mM.
Production platform:
HEK293 cells using the rPEx™ recombinant protein production platform.
Datasheet URL:
https://products.ipatherapeutics.com/product/v002/
| Storage temp. | -80°C | Manufacturer | ImmunoPrecise Antibodies (Europe) BV | ||
|---|---|---|---|---|---|
| Alternative names | Von Willebrand antigen II, Von Willebrand Factor, F8VWF | ||||
| Background | Product description: Human Von Willebrand Factor (VWF) is a multimeric glycoprotein, which is involved in binding coaggulaion factor VIII and in adhesion of platelets at sites of vascular damage. In this process the platelet receptor glycoprotein Ib-IX-V complex binds to the VWF-A1 domain. The VWF-A1 variant in this product contains Von Willebrand Disease type 2B mutation R1306Q, which induces spontaneous binding of the VWF-A1 domain to platelet receptor GpIb-IX-V complex. Residues 1261-1468 of human VWF containing mutation R1306Q were cloned, the protein was over-expressed and was purified to homogeneity. The calculated molecular weight of recombinant human VWF-A1 domain is 23.8 kDa. Reference sequences: Swiss-prot P04275 |
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